Wiseman Sam M, Masoudi Hamid, Niblock Paddy, Turbin Dmitry, Rajput Ashish, Hay John, Filipenko Douglas, Huntsman David, Gilks Blake
Department of Surgery, St. Paul's Hospital, University of British Columbia, C303-1081 Burrard St., Vancouver, British Columbia, Canada, V6Z-1Y6.
Am J Surg. 2006 May;191(5):581-7. doi: 10.1016/j.amjsurg.2006.02.005.
Anaplastic thyroid cancer arises, or transforms, from pre-existing differentiated thyroid cancer. E-cadherin functions as a cell-cell adhesion molecule that complexes with catenin proteins for function. The objective of this study was to evaluate the change in E-cadherin/beta-catenin expression in the transformation of differentiated to anaplastic thyroid carcinoma.
A tissue microarray was constructed from 12 anaplastic thyroid tumors and their adjacent associated differentiated foci. Immunohistochemistry was used to evaluate tumor expression of E-cadherin and beta-catenin.
There was decreased expression of E-cadherin and beta-catenin by the anaplastic tumors when compared with the differentiated thyroid tumors from which they evolved. The expression of E-cadherin and beta-catenin was 92% and 67%, respectively, by the differentiated thyroid carcinoma, and 17% and 50%, respectively, by the anaplastic tumors.
This report shows that derangement of the E-cadherin/catenin complex is associated with the transformation of differentiated into anaplastic thyroid carcinoma.
间变性甲状腺癌由先前存在的分化型甲状腺癌发生或转变而来。E-钙黏蛋白作为一种细胞间黏附分子，与连环蛋白结合发挥功能。本研究的目的是评估分化型甲状腺癌向间变性甲状腺癌转变过程中E-钙黏蛋白/β-连环蛋白表达的变化。
从12例间变性甲状腺肿瘤及其相邻的相关分化灶构建组织芯片。采用免疫组织化学方法评估肿瘤中E-钙黏蛋白和β-连环蛋白的表达。
与间变性肿瘤起源的分化型甲状腺肿瘤相比，间变性肿瘤中E-钙黏蛋白和β-连环蛋白的表达降低。分化型甲状腺癌中E-钙黏蛋白和β-连环蛋白的表达分别为92%和67%，间变性肿瘤中分别为17%和50%。
本报告表明，E-钙黏蛋白/连环蛋白复合物紊乱与分化型甲状腺癌向间变性甲状腺癌的转变有关。
