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1
Effects of adenosine 3':5'-cyclic monophosphate and guanine nucleotides on calcium-evoked ACTH release from electrically permeabilized AtT-20 cells.3':5'-环磷酸腺苷和鸟嘌呤核苷酸对钙诱导的电通透AtT-20细胞促肾上腺皮质激素释放的影响。
Br J Pharmacol. 1991 Sep;104(1):117-22. doi: 10.1111/j.1476-5381.1991.tb12394.x.
2
Effects of protein kinase C activators upon the late stages of the ACTH secretory pathway of AtT-20 cells.蛋白激酶C激活剂对AtT-20细胞促肾上腺皮质激素分泌途径后期阶段的影响。
Br J Pharmacol. 1994 Sep;113(1):171-8. doi: 10.1111/j.1476-5381.1994.tb16190.x.
3
Effects of mastoparan upon the late stages of the ACTH secretory pathway of AtT-20 cells.马斯托帕兰对AtT - 20细胞促肾上腺皮质激素分泌途径后期阶段的影响。
Br J Pharmacol. 1995 Jun;115(4):696-702. doi: 10.1111/j.1476-5381.1995.tb14989.x.
4
Involvement of multiple protein kinase C isozymes in the ACTH secretory pathway of AtT-20 cells.多种蛋白激酶C同工酶参与AtT-20细胞促肾上腺皮质激素分泌途径。
Br J Pharmacol. 1995 May;115(2):307-15. doi: 10.1111/j.1476-5381.1995.tb15878.x.
5
The effects of calyculin A upon calcium-, guanine nucleotides- and phorbol 12-myristate 13-acetate-stimulated ACTH secretion from AtT-20 cells.花萼海绵诱癌素A对钙离子、鸟嘌呤核苷酸及佛波酯刺激AtT - 20细胞促肾上腺皮质激素分泌的影响。
Br J Pharmacol. 1995 Apr;114(8):1571-6. doi: 10.1111/j.1476-5381.1995.tb14941.x.
6
The roles of adenosine 3',5'-cyclic monophosphate-dependent protein kinase A and protein kinase C in stimulus-secretion coupling in AtT-20 cells.3',5'-环磷酸腺苷依赖性蛋白激酶A和蛋白激酶C在AtT-20细胞刺激-分泌偶联中的作用。
J Mol Endocrinol. 1996 Apr;16(2):133-40. doi: 10.1677/jme.0.0160133.
7
A direct inhibitory action of prostaglandins upon ACTH secretion at the late stages of the secretory pathway of AtT-20 cells.前列腺素对AtT-20细胞分泌途径后期促肾上腺皮质激素分泌的直接抑制作用。
Br J Pharmacol. 2002 Apr;135(8):1851-8. doi: 10.1038/sj.bjp.0704652.
8
Dual regulation of ACTH secretion by guanine nucleotides in permeabilized AtT-20 cells.鸟嘌呤核苷酸对通透化AtT-20细胞促肾上腺皮质激素（ACTH）分泌的双重调节
Cell Mol Neurobiol. 1988 Mar;8(1):129-38. doi: 10.1007/BF00712918.
9
Adenosine 3',5'-cyclic monophosphate-mediated enhancement of calcium-evoked prolactin release from electrically permeabilised 7315c tumour cells.3',5'-环磷酸腺苷介导的钙诱发7315c肿瘤细胞电透化催乳素释放增强。
Br J Pharmacol. 1988 Jul;94(3):737-44. doi: 10.1111/j.1476-5381.1988.tb11583.x.
10
Reconstitution of calcium-regulated parathyroid hormone secretion from streptolysin-O-permeabilized parathyroid cells by guanosine 5'-O-(thio)triphosphate.通过鸟苷5'-O-（硫代）三磷酸从链球菌溶血素-O通透的甲状旁腺细胞重建钙调节的甲状旁腺激素分泌。
Endocrinology. 1997 Mar;138(3):1170-9. doi: 10.1210/endo.138.3.4971.

引用本文的文献

1
A direct inhibitory action of prostaglandins upon ACTH secretion at the late stages of the secretory pathway of AtT-20 cells.前列腺素对AtT-20细胞分泌途径后期促肾上腺皮质激素分泌的直接抑制作用。
Br J Pharmacol. 2002 Apr;135(8):1851-8. doi: 10.1038/sj.bjp.0704652.
2
Effects of protein kinase C activators upon the late stages of the ACTH secretory pathway of AtT-20 cells.蛋白激酶C激活剂对AtT-20细胞促肾上腺皮质激素分泌途径后期阶段的影响。
Br J Pharmacol. 1994 Sep;113(1):171-8. doi: 10.1111/j.1476-5381.1994.tb16190.x.
3
Feedback inhibition of nitric oxide synthase activity by nitric oxide.一氧化氮对一氧化氮合酶活性的反馈抑制
Br J Pharmacol. 1993 Mar;108(3):833-7. doi: 10.1111/j.1476-5381.1993.tb12886.x.
4
Involvement of multiple protein kinase C isozymes in the ACTH secretory pathway of AtT-20 cells.多种蛋白激酶C同工酶参与AtT-20细胞促肾上腺皮质激素分泌途径。
Br J Pharmacol. 1995 May;115(2):307-15. doi: 10.1111/j.1476-5381.1995.tb15878.x.
5
The effects of calyculin A upon calcium-, guanine nucleotides- and phorbol 12-myristate 13-acetate-stimulated ACTH secretion from AtT-20 cells.花萼海绵诱癌素A对钙离子、鸟嘌呤核苷酸及佛波酯刺激AtT - 20细胞促肾上腺皮质激素分泌的影响。
Br J Pharmacol. 1995 Apr;114(8):1571-6. doi: 10.1111/j.1476-5381.1995.tb14941.x.
6
Effects of mastoparan upon the late stages of the ACTH secretory pathway of AtT-20 cells.马斯托帕兰对AtT - 20细胞促肾上腺皮质激素分泌途径后期阶段的影响。
Br J Pharmacol. 1995 Jun;115(4):696-702. doi: 10.1111/j.1476-5381.1995.tb14989.x.

本文引用的文献

1
THE DEPENDENCE OF CONTRACTION AND RELAXATION OF MUSCLE FIBRES FROM THE CRAB MAIA SQUINADO ON THE INTERNAL CONCENTRATION OF FREE CALCIUM IONS.螃蟹（黄道蟹）肌纤维收缩与舒张对游离钙离子胞内浓度的依赖性
Biochim Biophys Acta. 1964 May 25;79:581-91. doi: 10.1016/0926-6577(64)90224-4.
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Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium.用于测量细胞内游离钙的中性载体离子选择性微电极。
Biochim Biophys Acta. 1980 Jul;599(2):623-38. doi: 10.1016/0005-2736(80)90205-9.
3
Calcium-dependence of catecholamine release from bovine adrenal medullary cells after exposure to intense electric fields.暴露于强电场后牛肾上腺髓质细胞儿茶酚胺释放的钙依赖性
J Membr Biol. 1982;68(2):107-40. doi: 10.1007/BF01872259.
4
Mechanisms of action of corticotropin-releasing factor and other regulators of corticotropin release in rat pituitary cells.促肾上腺皮质激素释放因子及其他大鼠垂体细胞促肾上腺皮质激素释放调节因子的作用机制
J Biol Chem. 1983 Jul 10;258(13):8039-45.
5
Forskolin stimulates adenylate cyclase activity, cyclic AMP accumulation, and adrenocorticotropin secretion from mouse anterior pituitary tumor cells.福斯高林可刺激小鼠垂体前叶肿瘤细胞的腺苷酸环化酶活性、环磷酸腺苷积累以及促肾上腺皮质激素分泌。
J Neurochem. 1984 Jun;42(6):1659-66. doi: 10.1111/j.1471-4159.1984.tb12757.x.
6
Stress hormones: their interaction and regulation.应激激素：它们的相互作用与调节
Science. 1984 May 4;224(4648):452-9. doi: 10.1126/science.6143403.
7
Somatostatin desensitization: loss of the ability of somatostatin to inhibit cyclic AMP accumulation and adrenocorticotropin hormone release.生长抑素脱敏：生长抑素抑制环磷酸腺苷积累和促肾上腺皮质激素释放能力的丧失。
J Pharmacol Exp Ther. 1984 Apr;229(1):14-20.
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Adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase activity in rodent pituitary tissue: possible role in cAMP-dependent hormone secretion.
Endocrinology. 1984 Nov;115(5):1933-45. doi: 10.1210/endo-115-5-1933.
9
Hormonal activation of the cAMP-dependent protein kinases in AtT20 cells. Preferential activation of protein kinase I by corticotropin releasing factor, isoproterenol, and forskolin.促肾上腺皮质激素释放因子、异丙肾上腺素和福斯高林对AtT20细胞中环磷酸腺苷依赖性蛋白激酶的激素激活作用。蛋白激酶I被促肾上腺皮质激素释放因子、异丙肾上腺素和福斯高林优先激活。
J Biol Chem. 1984 Aug 25;259(16):10296-302.
10
Stimulus-secretion coupling: the concept and clues from chromaffin and other cells.刺激-分泌偶联：来自嗜铬细胞及其他细胞的概念与线索
Br J Pharmacol. 1968 Nov;34(3):451-74. doi: 10.1111/j.1476-5381.1968.tb08474.x.

3':5'-环磷酸腺苷和鸟嘌呤核苷酸对钙诱导的电通透AtT-20细胞促肾上腺皮质激素释放的影响。

Effects of adenosine 3':5'-cyclic monophosphate and guanine nucleotides on calcium-evoked ACTH release from electrically permeabilized AtT-20 cells.

作者信息

Guild S

机构信息

Department of Pharmacology, University of Glasgow.

出版信息

Br J Pharmacol. 1991 Sep;104(1):117-22. doi: 10.1111/j.1476-5381.1991.tb12394.x.

DOI:10.1111/j.1476-5381.1991.tb12394.x
PMID:1664757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1908274/
Abstract
  1. The mouse AtT-20/D16-16 anterior pituitary tumour cell line was used as a model system for the investigation of adenosine 3':5'-cyclic monophosphate (cyclic AMP)-mediated enhancement of calcium-evoked adrenocorticotrophin (ACTH) secretion. 2. AtT-20 cells were permeabilized by subjecting the cells to intense electric fields. Exposure of permeabilized cells to calcium (1 mM) in the external medium significantly stimulated ACTH secretion over the first 20 min of exposure. This calcium-stimulated ACTH secretion was dependent upon the presence of MgATP (5 mM). 3. The amount of ACTH secreted, in a 20 min incubation at 37 degrees C, from permeabilized cells depended upon the free calcium concentration in the permeabilization medium. Calcium stimulated ACTH secretion from permeabilized cells in the concentration range of 10(-7)-10(-5) M (half maximal = 7 x 10(-7) M). Cyclic AMP(10(-4) M) increased the amount of ACTH secreted at each effective concentration of calcium. However, cyclic AMP did not alter the potency of calcium as a stimulant of ACTH secretion. 4. Guanosine 5'-O-(3-thiotriphosphate) (GTP-gamma-S, 10(-4) M) stimulated ACTH secretion from permeabilized cells in the absence of calcium and was additive with calcium-evoked ACTH secretion up to a maximum which could be stimulated by calcium acting singly. Guanosine 5'-O-(2-thiodiphosphate) (GDP-beta-S, 10(-4) M) inhibited calcium-evoked ACTH secretion from permeabilized cells. 5. GTP-gamma-S stimulated ACTH secretion from permeabilized cells in a concentration-dependent manner. The nucleotide significantly stimulated ACTH secretion at concentrations of 10-'M and above. Cyclic AMP (10-4 M) increased the amount of ACTH secretion evoked by effective concentrations of GTP-y-S.6. The results of the present study support the hypothesis that, in AtT-20 cells, cyclic AMP is acting at some site, distal to calcium entry, which modulates the ability of an increase in cytosolic calcium concentration to stimulate ACTH secretion. One such site may be a GTP-binding protein which the present study suggests may mediate the effects of calcium upon the secretory apparatus. These GTP-binding proteins may be a target for regulation by cyclic AMP.
摘要
  1. 小鼠AtT-20/D16-16垂体前叶肿瘤细胞系被用作一个模型系统，用于研究3':5'-环磷酸腺苷（环磷腺苷）介导的钙诱发促肾上腺皮质激素（ACTH）分泌增强作用。2. 通过对AtT-20细胞施加强电场使其透化。在外部培养基中，将透化细胞暴露于钙（1 mM）下，在暴露的前20分钟内显著刺激了ACTH分泌。这种钙刺激的ACTH分泌依赖于MgATP（5 mM）的存在。3. 在37℃孵育20分钟时，透化细胞分泌的ACTH量取决于透化培养基中的游离钙浓度。钙在10⁻⁷ - 10⁻⁵ M的浓度范围内刺激透化细胞分泌ACTH（半数最大效应浓度 = 7×10⁻⁷ M）。环磷腺苷（10⁻⁴ M）在每个有效的钙浓度下都增加了ACTH的分泌量。然而，环磷腺苷并没有改变钙作为ACTH分泌刺激物的效力。4. 5'-O-(3-硫代三磷酸)鸟苷（GTP-γ-S，10⁻⁴ M）在无钙的情况下刺激透化细胞分泌ACTH，并且与钙诱发的ACTH分泌相加，直至达到单独钙刺激所能达到的最大值。5'-O-(2-硫代二磷酸)鸟苷（GDP-β-S，10⁻⁴ M）抑制透化细胞的钙诱发ACTH分泌。5. GTP-γ-S以浓度依赖的方式刺激透化细胞分泌ACTH。该核苷酸在10⁻⁶ M及以上的浓度下显著刺激ACTH分泌。环磷腺苷（10⁻⁴ M）增加了有效浓度的GTP-γ-S诱发的ACTH分泌量。6. 本研究结果支持以下假设：在AtT-20细胞中，环磷腺苷在钙进入细胞的远端某个位点起作用，调节细胞质钙浓度增加刺激ACTH分泌的能力。一个这样的位点可能是一种GTP结合蛋白，本研究表明它可能介导钙对分泌装置的作用。这些GTP结合蛋白可能是环磷腺苷调节的靶点。