Menegon Michela, Majori Giancarlo, Severini Carlo
Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
Acta Trop. 2006 May;98(2):196-9. doi: 10.1016/j.actatropica.2006.03.003. Epub 2006 May 2.
Dihydropteroate synthase gene of Plasmodium vivax was recently identified. In the present study, the sequences of the dyhydropteroate synthase gene of 68 P. vivax isolates from various geographic areas were compared. Sequencing revealed limited polymorphism at codons 383 and 553 in all analyzed samples. Interstrain analysis showed several genotypic variations in the tandem repeats domain which produce length polymorphism between different parasite isolates.
间日疟原虫二氢蝶酸合酶基因最近已被鉴定。在本研究中，对来自不同地理区域的68株间日疟原虫分离株的二氢蝶酸合酶基因序列进行了比较。测序显示，在所有分析样本中，密码子383和553处的多态性有限。菌株间分析显示，串联重复结构域存在几种基因型变异，这些变异在不同的寄生虫分离株之间产生长度多态性。
