Sanders David L, Gregg William, Aronsky Dominik
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232-8340, United States.
Int J Med Inform. 2007 Jul;76(7):557-64. doi: 10.1016/j.ijmedinf.2006.03.003. Epub 2006 May 2.
Asthma is a common pediatric chronic disease and is estimated to account for more than 2million emergency department visits per year. Asthma guidelines have demonstrated improved outcomes, but remain underutilized due to several barriers. Computerized methods to automatically identify asthma exacerbations may be beneficial to initiate guideline recommended treatment, but have not been described. The goal of the study was to examine the accuracy of an algorithm to identify asthma patients at triage in real-time using only electronically available data.
During a 9-month period, the five most frequent presenting chief complaints for Emergency Department asthma patients aged 2-18 years were identified and accounted for >95% of asthma visits: wheezing, shortness of breath, fever, cough, and dyspnea. During a following 1-month period (November 2004), medical records of all patients with one of the five chief complaints were reviewed to establish a reference standard diagnosis. An asthma identification algorithm was developed that considered only data available in electronic format at the time of triage and included the presenting chief complaint, information from the computerized problem list (past medical history; current medications, such as beta-agonists, steroids, and other asthma medications), and ICD-9 billing codes from previous encounters.
From 1835 Emergency Department visits, 368 visits (154 with asthma) had one of the five chief complaints and were included. A problem list was available in 203 (55.2%) and an ICD-9 code in 68 (18.5%) patients. Wheezing accounted for 56.5% of asthma visits, while fever was the most frequent chief complaint among all patients (43.8%). The asthma identification algorithm had a sensitivity of 44.8% (95% CI: 36.8-53.0%), a specificity of 91.6% (CI: 87.0-94.9%), a positive predictive value of 79.3% (CI: 69.3-87.3%) and a negative predictive value of 69.8% (CI: 64.0-75.1%). The positive and negative likelihood ratios were 5.3 (CI: 3.3-8.6) and 0.6 (CI: 0.5-0.7), respectively.
The simple identification algorithm demonstrated good accuracy for identifying asthma episodes. The algorithm may represent a promising and feasible approach to create computerized reminders or automatic triggers that can facilitate the initiation of guideline-based asthma treatment in the Emergency Department.
哮喘是一种常见的儿科慢性疾病,据估计每年有超过200万次急诊就诊。哮喘指南已证明能改善治疗效果,但由于多种障碍,其应用仍未得到充分利用。自动识别哮喘急性发作的计算机化方法可能有助于启动指南推荐的治疗,但尚未见相关描述。本研究的目的是检验一种算法在仅使用电子可得数据的情况下实时识别分诊时哮喘患者的准确性。
在9个月期间,确定了2至18岁急诊科哮喘患者最常见的五种主要就诊主诉,这些主诉占哮喘就诊的95%以上:喘息、呼吸急促、发热、咳嗽和呼吸困难。在随后的1个月期间(2004年11月),对所有有这五种主要主诉之一的患者的病历进行审查,以建立参考标准诊断。开发了一种哮喘识别算法,该算法仅考虑分诊时以电子格式可得的数据,包括就诊时的主要主诉、计算机化问题列表中的信息(既往病史;当前用药,如β受体激动剂、类固醇和其他哮喘药物)以及既往就诊的ICD - 9计费代码。
在1835次急诊科就诊中,368次就诊(154次为哮喘患者)有这五种主要主诉之一并被纳入研究。203名患者(55.2%)有问题列表,68名患者(18.5%)有ICD - 9代码。喘息占哮喘就诊的56.5%,而发热是所有患者中最常见的主要主诉(43.8%)。哮喘识别算法的敏感性为44.8%(95%可信区间:36.8 - 53.0%),特异性为91.6%(可信区间:87.0 - 94.9%),阳性预测值为79.3%(可信区间:69.3 - 87.3%),阴性预测值为69.8%(可信区间:64.0 - 75.1%)。阳性和阴性似然比分别为5.3(可信区间:3.3 - 8.6)和0.6(可信区间:0.5 - 0.7)。
该简单识别算法在识别哮喘发作方面显示出良好的准确性。该算法可能代表一种有前景且可行的方法,可创建计算机化提醒或自动触发机制,以促进急诊科基于指南的哮喘治疗的启动。