滤泡性淋巴瘤3B级的分子、细胞遗传学及免疫表型特征；是一个独立的实体，还是弥漫性大B细胞淋巴瘤或滤泡性淋巴瘤谱系的一部分？

Molecular, cytogenetic, and immunophenotypic characterization of follicular lymphoma grade 3B; a separate entity or part of the spectrum of diffuse large B-cell lymphoma or follicular lymphoma?

作者信息

Bosga-Bouwer Anneke G, van den Berg Anke, Haralambieva Eugenia, de Jong Debora, Boonstra Ronald, Kluin Philip, van den Berg Eva, Poppema Sibrand

机构信息

Department of Medical Genetics, University Medical Center Groningen, and University of Groningen, 9713AW Groningen, The Netherlands.

出版信息

Hum Pathol. 2006 May;37(5):528-33. doi: 10.1016/j.humpath.2005.12.005.

DOI:10.1016/j.humpath.2005.12.005

PMID:16647949

Abstract

We studied a histological homogeneous group of 29 cases with the diagnosis of follicular lymphoma (FL) grade 3B (FL3Bs). In a previous study, we subdivided this group in 3 subgroups based on (1) aberrations of the 3q27 region, (2) lack of 3q27 and t(14;18), and (3) the presence of a t(14;18). In this study, we further characterized the FL3B lymphomas that are currently part of the spectrum of FL in the WHO classification, taking into account other cytogenetical aberrations, immunohistochemistry for P53, bcl2, bcl6, and CD10, rearrangement of the proto-oncogene myc, and mutation of the tumor suppressor gene TP53. With respect to P53, bcl2, bcl6 expression, myc rearrangement, and TP53 mutation, FL3B represents a homogeneous group. CD10 expression and gain of chromosome 7, considered to be typical FL markers, were more common in the FL3B t(14;18)-positive subgroup. The lack of CD10 expression and gain of chromosome 7 in most cases in the other 2 subgroups suggest that those cases have a closer relation to diffuse large B-cell lymphomas.

摘要

我们研究了一组组织学特征均一的29例诊断为3B级滤泡性淋巴瘤（FL3B）的病例。在先前的一项研究中，我们根据（1）3q27区域的畸变、（2）无3q27和t(14;18)以及（3）存在t(14;18)将该组病例分为3个亚组。在本研究中，我们进一步对目前WHO分类中FL谱系一部分的FL3B淋巴瘤进行了特征描述，同时考虑了其他细胞遗传学畸变、P53、bcl2、bcl6和CD10的免疫组化、原癌基因myc的重排以及肿瘤抑制基因TP⁵³的突变。关于P53、bcl2、bcl6表达、myc重排和TP⁵³突变，FL3B代表一个均一的组。CD10表达和7号染色体增多，被认为是典型的FL标志物，在FL3B t(14;18)阳性亚组中更为常见。其他2个亚组中大多数病例缺乏CD10表达和7号染色体增多，提示这些病例与弥漫性大B细胞淋巴瘤关系更为密切。