• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Mechanism of inactivation of gamma-cystathionase by the acetylenic substrate analogue propargylglycine.

作者信息

Washtien W, Abeles R H

出版信息

Biochemistry. 1977 May 31;16(11):2485-91. doi: 10.1021/bi00630a026.

DOI:10.1021/bi00630a026
PMID:16648
Abstract
摘要

相似文献

1
Mechanism of inactivation of gamma-cystathionase by the acetylenic substrate analogue propargylglycine.
Biochemistry. 1977 May 31;16(11):2485-91. doi: 10.1021/bi00630a026.
2
Suicide inactivation of bacterial cystathionine gamma-synthase and methionine gamma-lyase during processing of L-propargylglycine.L-炔丙基甘氨酸加工过程中细菌胱硫醚γ-合酶和蛋氨酸γ-裂解酶的自杀失活
Biochemistry. 1979 Oct 16;18(21):4690-701. doi: 10.1021/bi00588a033.
3
Acetylenic enzyme inactivators. Inactivation of gamma-cystathionase, in vitro and in vivo, by propargylglycine.炔类酶失活剂。炔丙基甘氨酸在体外和体内对γ-胱硫醚酶的失活作用。
J Am Chem Soc. 1973 Sep 5;95(18):6124-5. doi: 10.1021/ja00799a053.
4
Inactivation of gamma-cystathionase by gamma-fluorinated amino acids.γ-氟代氨基酸使γ-胱硫醚酶失活。
FEBS Lett. 1981 Jun 15;128(2):293-7. doi: 10.1016/0014-5793(81)80102-0.
5
Mechanism of inactivation of gamma-cystathionase by beta,beta,beta-trifluoroalanine.
Biochemistry. 1977 Dec 13;16(25):5515-20. doi: 10.1021/bi00644a019.
6
Identification of the active-site residue of gamma-cystathionase labeled by the suicide inactivator beta, beta, beta-trifluoroalanine.通过自杀性失活剂β,β,β-三氟丙氨酸标记鉴定γ-胱硫醚酶的活性位点残基。
Biochemistry. 1982 Aug 3;21(16):3790-4. doi: 10.1021/bi00259a011.
7
Role of the transsulfuration pathway and of gamma-cystathionase activity in the formation of cysteine and sulfate from methionine in rat hepatocytes.转硫途径及γ-胱硫醚酶活性在大鼠肝细胞中由蛋氨酸形成半胱氨酸和硫酸盐过程中的作用。
J Nutr. 1990 Aug;120(8):837-45. doi: 10.1093/jn/120.8.837.
8
Effect of cysteine on the inactivation of cystathionine gamma-lyase by D,L-propargylglycine.半胱氨酸对D,L-炔丙基甘氨酸使胱硫醚γ-裂解酶失活的影响。
Acta Med Okayama. 1989 Dec;43(6):329-35. doi: 10.18926/AMO/30862.
9
Effect of D,L-propargylglycine on cystathionine metabolism in rats.D,L-炔丙基甘氨酸对大鼠胱硫醚代谢的影响。
Biochem Int. 1984 Jan;8(1):171-9.
10
Metabolic consequences of affinity labeling of cystathionase and alanine aminotransferase by L-propargylglycine in vivo.
Eur J Biochem. 1982 May 17;124(2):377-82. doi: 10.1111/j.1432-1033.1982.tb06603.x.

引用本文的文献

1
Terminal alkyne formation by a pyridoxal phosphate-dependent enzyme.由磷酸吡哆醛依赖性酶催化的末端炔烃形成
Nat Chem Biol. 2025 Jun 25. doi: 10.1038/s41589-025-01954-9.
2
HS biosynthesis and catabolism: new insights from molecular studies.硫酸乙酰肝素的生物合成与分解代谢:分子研究的新见解
Cell Mol Life Sci. 2017 Apr;74(8):1391-1412. doi: 10.1007/s00018-016-2406-8. Epub 2016 Nov 14.
3
Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate.
缺乏半胱氨酸双加氧酶的小鼠原代肝细胞中半胱氨酸浓度增加,且半胱氨酸代谢为硫化氢和硫代硫酸盐的速率更高。
Amino Acids. 2014 May;46(5):1353-65. doi: 10.1007/s00726-014-1700-8. Epub 2014 Mar 8.
4
Beneficial effects of diminished production of hydrogen sulfide or carbon monoxide on hypertension and renal injury induced by NO withdrawal.硫化氢或一氧化碳生成减少对因一氧化氮撤离所致高血压和肾损伤的有益作用。
Br J Pharmacol. 2015 Mar;172(6):1607-19. doi: 10.1111/bph.12674. Epub 2014 Jul 2.
5
Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema.CO-H2S 介导的颈动脉体 O2 传感固有变异性介导高血压和肺水肿。
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1174-9. doi: 10.1073/pnas.1322172111. Epub 2014 Jan 6.
6
Endogenous H2S is required for hypoxic sensing by carotid body glomus cells.内源性 H2S 是颈动脉体球细胞缺氧感应所必需的。
Am J Physiol Cell Physiol. 2012 Nov 1;303(9):C916-23. doi: 10.1152/ajpcell.00100.2012. Epub 2012 Jun 27.
7
Carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body.颈动脉体对低氧感应中的一氧化碳(CO)和硫化氢(H(2)S)。
Respir Physiol Neurobiol. 2012 Nov 15;184(2):165-9. doi: 10.1016/j.resp.2012.05.022. Epub 2012 Jun 2.
8
Gaseous messengers in oxygen sensing.气体信使在氧感应中的作用。
J Mol Med (Berl). 2012 Mar;90(3):265-72. doi: 10.1007/s00109-012-0876-1. Epub 2012 Feb 16.
9
Cysteinyl-glycine in the control of glutathione homeostasis in bovine lenses.半胱氨酰甘氨酸对牛晶状体中谷胱甘肽稳态的调控作用
Mol Vis. 2010 Jun 5;16:1025-33.
10
H2S mediates O2 sensing in the carotid body.H2S 介导颈动脉体中的氧感测。
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10719-24. doi: 10.1073/pnas.1005866107.