Dihydrogenated ergot compounds bind with high affinity to GABAA receptor-associated Cl- ionophore. - Suppr | 超能文献

Dihydrogenated ergot compounds bind with high affinity to GABAA receptor-associated Cl- ionophore.

作者信息

Tvrdeić A, Pericić D

机构信息

Ruder Bosković Institute, Department of Experimental Biology and Medicine, Zagreb, Croatia, Yugoslavia.

出版信息

Eur J Pharmacol. 1991 Sep 4;202(1):109-11. doi: 10.1016/0014-2999(91)90262-o.

DOI:10.1016/0014-2999(91)90262-o

Abstract

The binding of t-[3H]butylbicycloorthobenzoate ([3H]TBOB) to crude synaptosomal membranes of the mouse brain (cerebrum minus cortex) in the presence of dihydroergotoxine, dihydroergosine, dihydroergotamine and gamma-aminobutyric acid (GABA) was studied in vitro. [3H]TBOB binding was inhibited by all drugs used. The rank order of potency was dihydroergotoxine greater than GABA greater than dihydroergosine greater than dihydroergotamine. This suggests that dihydrogenated ergot compounds, especially dihydroergotoxine, possess appreciable binding activity (comparable to that of benzodiazepines and barbiturates) at the GABAA receptor-associated C1- ionophore.

摘要

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引用本文的文献

1

Species dependent effects of dihydroergosine on [3H]TBOB binding to membranes from the human, rat, bovine and mouse brain.二氢麦角灵对[³H]TBOB与人、大鼠、牛和小鼠脑细胞膜结合的物种依赖性影响。

J Neural Transm Gen Sect. 1992;90(3):225-30. doi: 10.1007/BF01250963.

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