双氢麦角毒碱对小鼠脑内GABAA受体相关氯离子载体的调节作用。
Dihydroergotoxine modulation of the GABAA receptor-associated Cl- ionophore in mouse brain.
作者信息
Tvrdeić A, Pericić D
机构信息
Ruder Bosković Institute, Laboratory for Molecular Neuropharmacology, Zagreb, Croatia.
出版信息
Eur J Pharmacol. 1992 Oct 6;221(1):139-43. doi: 10.1016/0014-2999(92)90783-z.
Dihydroergotoxine non-competitively displaced the binding of t-[3H]butylbicycloorthobenzoate ([3H]TBOB) to crude synaptosomal membranes from the mouse brain (cerebrum minus cortex), and gamma-aminobutyric acid (GABA) (10 microM) enhanced the displacement potency of dihydroergotoxine in a bicuculline-sensitive manner. The same ergot compound prolonged pentobarbital-induced sleeping in mice and diminished the convulsive potency of picrotoxin in the same animal species. The results are indicative of the positive coupling between GABA and dihydroergotoxine.
双氢麦角毒碱非竞争性地取代了t-[3H]丁基双环邻苯二甲酸酯（[3H]TBOB）与小鼠脑（大脑皮质除外）粗制突触体膜的结合，γ-氨基丁酸（GABA）（10微摩尔）以荷包牡丹碱敏感的方式增强了双氢麦角毒碱的取代效力。同一麦角化合物延长了戊巴比妥诱导的小鼠睡眠时间，并降低了同一动物物种中匹鲁卡品的惊厥效力。结果表明GABA与双氢麦角毒碱之间存在正偶联。
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