Babulas Vicki, Factor-Litvak Pam, Goetz Raymond, Schaefer Catherine A, Brown Alan S
New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA.
Am J Psychiatry. 2006 May;163(5):927-9. doi: 10.1176/ajp.2006.163.5.927.
In this birth cohort study, the authors examined the relation between prenatal exposure to maternal genital/reproductive (G/R) infections and schizophrenia in offspring.
The birth cohort consisted of 7,794 offspring of pregnancies with prospectively acquired data on maternal G/R infections from obstetric records. The authors diagnosed 71 cases of schizophrenia and other schizophrenia spectrum disorders in this cohort. The relationship between maternal G/R infections and schizophrenia risk was modeled.
Exposure to G/R infections during the periconceptional period was associated with a significantly increased risk of schizophrenia and other schizophrenia spectrum disorders, with adjustment for maternal race, education, age, and mental illness.
Maternal G/R infection during periconception appears to increase the risk of schizophrenia in offspring.
在这项出生队列研究中，作者研究了孕期母亲生殖器/生殖系统（G/R）感染与后代精神分裂症之间的关系。
该出生队列由7794名妊娠后代组成，这些妊娠的产科记录中有关于母亲G/R感染的前瞻性获取数据。作者在该队列中诊断出71例精神分裂症和其他精神分裂症谱系障碍病例。对母亲G/R感染与精神分裂症风险之间的关系进行了建模。
在调整了母亲的种族、教育程度、年龄和精神疾病因素后，受孕期间暴露于G/R感染与精神分裂症和其他精神分裂症谱系障碍的风险显著增加相关。
受孕期间母亲的G/R感染似乎会增加后代患精神分裂症的风险。
