单剂量头孢地嗪可完全根除尿道炎和宫颈炎中的耐多药淋病奈瑟菌菌株。

Single dose of cefodizime completely eradicated multidrug-resistant strain of Neisseria gonorrhoeae in urethritis and uterine cervicitis.

作者信息

Matsumoto Tetsuro, Muratani Tetsuro, Takahashi Koichi, Ando Yukiko, Sato Yumiko, Kurashima Masako, Yokoo Daisuke, Ikuyama Toshihiro, Shimokawa Hiroshi, Yanai Shigeaki

机构信息

Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

出版信息

J Infect Chemother. 2006 Apr;12(2):97-9. doi: 10.1007/s10156-006-0431-5.

DOI:10.1007/s10156-006-0431-5

PMID:16648949

Abstract

Cefodizime (CDZM) has strong antimicrobial activity to Neisseria gonorrhoeae in vitro. However, multidrug-resistant N. gonorrhoea emerged and has been increasing in Japan. To know the effectiveness of CDZM on gonococcal urethritis and uterine cervicitis even in the era of multidrug-resistant N. gonorrhoeae, a clinical trial of single-dose therapy of CDZM for gonococcal urethritis and uterine cervicitis was conducted. N. gonorrhoeae was eradicated from 100% of patients with gonococcal urethritis and uterine cervicitis by a single dose of CDZM. In conclusion, CDZM is one of most suitable drugs for the treatment of gonococcal genital infection in the era of multidrug-resistant N. gonorrhoeae.

摘要

头孢地嗪（CDZM）在体外对淋病奈瑟菌具有很强的抗菌活性。然而，耐多药淋病奈瑟菌在日本出现且一直在增加。为了解即使在耐多药淋病奈瑟菌时代CDZM对淋菌性尿道炎和宫颈炎的疗效，开展了一项CDZM单剂量治疗淋菌性尿道炎和宫颈炎的临床试验。单剂量CDZM可使100%的淋菌性尿道炎和宫颈炎患者的淋病奈瑟菌被清除。总之，在耐多药淋病奈瑟菌时代，CDZM是治疗淋菌性生殖器感染最合适的药物之一。