Otubu J A, Imade G E, Sagay A S, Towobola O A
Dept. of Obstetrics and Gynaecology, Faculty of Medical Sciences, University of Jos, Nigeria.
Infection. 1992 Nov-Dec;20(6):339-41. doi: 10.1007/BF01710680.
One hundred four patients (71 males, 33 females) with acute gonococcal urethritis or cervicitis were treated with a single oral 250 mg dose of ciprofloxacin at Jos University Teaching Hospital, Jos, Nigeria. All gonococcal strains were isolated from appropriate pre-treatment swabs. Penicillinase-producing Neisseria gonorrhoeae (PPNG) accounted for 72.8% of all isolates. In vitro sensitivity of gonococcal isolates to ciprofloxacin was 100%, while that to penicillin, ampicillin and co-trimoxazole was below 15%. Of the 104 patients treated with ciprofloxacin, 73 (70%) attended a follow-up visit. Seventy-three (100%) patients showed clinical cure and elimination of N. gonorrhoeae from the respective site of infection. Post-gonococcal urethritis or cervicitis believed to be due to concomitant chlamydial infection was found in 22 (30.1%) patients--18 males and four females. No adverse reactions were reported by any patient. Our findings show that a single oral dose of ciprofloxacin (250 mg) is well tolerated and effective in the treatment of uncomplicated gonorrhoea and is particularly useful in regions with a high prevalence of PPNG.
在尼日利亚乔斯市的乔斯大学教学医院，104例急性淋菌性尿道炎或宫颈炎患者（71例男性，33例女性）接受了单次口服250毫克环丙沙星的治疗。所有淋球菌菌株均从适当的治疗前拭子中分离出来。产青霉素酶淋病奈瑟菌（PPNG）占所有分离株的72.8%。淋球菌分离株对环丙沙星的体外敏感性为100%，而对青霉素、氨苄西林和复方新诺明的敏感性低于15%。在接受环丙沙星治疗的104例患者中，73例（70%）进行了随访。73例（100%）患者临床治愈，感染部位的淋病奈瑟菌被清除。22例（30.1%）患者——18例男性和4例女性，发现了被认为是由衣原体合并感染引起的淋菌性尿道炎或宫颈炎后炎症。没有任何患者报告不良反应。我们的研究结果表明，单次口服剂量的环丙沙星（250毫克）耐受性良好，对单纯性淋病有效，在PPNG高发地区尤其有用。
