Hori Seiji, Kizu Junko, Kawamura Masahiro
Department of Pharmacology (I), Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan.
J Infect Chemother. 2006 Apr;12(2):109-11. doi: 10.1007/s10156-006-0429-z.
In fasted mice, plasma glucose levels were reduced by intraperitoneal administration of enoxacin, lomefloxacin, or gatifloxacin (50 mg/kg). A lower dose of these fluoroquinolones (5 mg/kg) also reduced the plasma glucose (PG) levels in glucose-loaded mice. Ciprofloxacin and levofloxacin did not reduce these levels in either fasted or glucose-loaded mice. These results suggest that each fluoroquinolone has an individual hypoglycemic action, and fluoroquinolone administration after meals might reduce PG levels at lower doses.
在禁食小鼠中，腹腔注射依诺沙星、洛美沙星或加替沙星（50毫克/千克）可降低血浆葡萄糖水平。较低剂量的这些氟喹诺酮类药物（5毫克/千克）也可降低葡萄糖负荷小鼠的血浆葡萄糖（PG）水平。环丙沙星和左氧氟沙星在禁食或葡萄糖负荷小鼠中均未降低这些水平。这些结果表明，每种氟喹诺酮类药物都有单独的降血糖作用，餐后服用氟喹诺酮类药物可能以较低剂量降低PG水平。
