抑制钠依赖性钙超载以治疗心肌缺血。
Inhibition of sodium-dependent calcium overload to treat myocardial ischemia.
作者信息
Conti C R
出版信息
Clin Cardiol. 2006 Apr;29(4):141-3. doi: 10.1002/clc.4960290403.
Abstract
Because intracellular sodium and calcium overload play a key role in both mechanical and electrical dysfunction during myocardial ischemia, inhibition of the late sodium current would be expected to decrease the intracellular sodium and calcium overloads and thereby reduce their undesirable effects. Ranolazine selectively inhibits late sodium current relative to peak sodium current, and attenuates the abnormalities of ventricular repolarization and contractility associated with ischemia. This is the currently proposed mechanism (hypothesis) of action of the effects of ranolazine during myocardial ischemia.
摘要
由于细胞内钠和钙超载在心肌缺血期间的机械和电功能障碍中起关键作用，因此抑制晚钠电流有望减少细胞内钠和钙超载，从而降低其不良影响。相对于峰值钠电流，雷诺嗪选择性抑制晚钠电流，并减轻与缺血相关的心室复极化和收缩力异常。这是目前所提出的雷诺嗪在心肌缺血期间发挥作用的机制（假说）。
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