Turner Patricia V, Kerr Carolyn L, Healy Amanda J, Taylor W Michael
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
Am J Vet Res. 2006 May;67(5):770-4. doi: 10.2460/ajvr.67.5.770.
To determine the effects of meloxicam and butorphanol on minimum alveolar concentration of isoflurane (MAC(ISO)) in rabbits.
10 healthy young adult female rabbits.
Rabbits were anesthetized with isoflurane on 3 occasions in a blinded, randomized complete block design to determine the MAC(ISO) associated with administration of meloxicam (0, 0.3, or 1.5 mg/kg, PO) and butorphanol (0.4 mg/kg, IV). The MAC(ISO) was determined by use of a paw clamp technique as the end-tidal concentration of isoflurane halfway between the values that allowed or inhibited purposeful movement. Rectal temperature, end-tidal CO2 concentration, heart rate, oxygen saturation, and arterial blood pressure were measured to evaluate cardiopulmonary function.
Mean +/- SE MAC(ISO) in saline (0.9% NaCl) solution-treated rabbits was 2.49 +/- 0.07% and was not significantly different from that associated with administration of meloxicam at 0.3 mg/kg (2.56 +/- 0.07%) or 1.5 mg/kg (2.66 +/- 0.07%). Butorphanol significantly reduced the MAC(ISO) to 2.30 +/- 0.07% when administered with saline solution alone, 2.27 +/- 0.07% when administered with 0.3 mg of meloxicam/kg, and 2.33 +/- 0.07% when administered with 1.5 mg of meloxicam/kg. The percentage reduction in MAC(ISO) was significantly greater for rabbits that received butorphanol and meloxicam at either dose, compared with butorphanol and saline solution.
Results indicated that meloxicam does not have a direct isoflurane-sparing effect and does not interfere with the anesthetic-sparing effect of butorphanol in rabbits.
确定美洛昔康和布托啡诺对兔异氟烷最低肺泡浓度（MAC(ISO)）的影响。
10只健康的成年雌性幼兔。
采用盲法、随机完全区组设计，对兔进行3次异氟烷麻醉，以确定与美洛昔康（0、0.3或1.5mg/kg，口服）和布托啡诺（0.4mg/kg，静脉注射）给药相关的MAC(ISO)。MAC(ISO)通过爪夹技术测定，即异氟烷呼气末浓度处于允许或抑制有目的运动的数值之间的中点。测量直肠温度、呼气末二氧化碳浓度、心率、血氧饱和度和动脉血压以评估心肺功能。
用生理盐水（0.9%氯化钠）溶液处理的兔的平均±标准误MAC(ISO)为2.49±0.07%，与给予0.3mg/kg（2.56±0.07%）或1.5mg/kg（2.66±0.07%）美洛昔康时的MAC(ISO)无显著差异。单独与生理盐水溶液一起给药时，布托啡诺可将MAC(ISO)显著降低至2.30±0.07%；与0.3mg美洛昔康/kg一起给药时，降低至2.27±0.07%；与1.5mg美洛昔康/kg一起给药时，降低至2.33±0.07%。与布托啡诺和生理盐水溶液相比，接受任一剂量布托啡诺和美洛昔康的兔的MAC(ISO)降低百分比显著更大。
结果表明，美洛昔康对兔没有直接的异氟烷节省效应，也不干扰布托啡诺的麻醉节省效应。
