对乙酰氨基酚单独及与吗啡和曲马多联合使用对大鼠异氟烷最低肺泡浓度的影响。

Effect of Acetaminophen Alone and in Combination with Morphine and Tramadol on the Minimum Alveolar Concentration of Isoflurane in Rats.

作者信息

Chavez Julio R, Ibancovichi José A, Sanchez-Aparicio Pedro, Acevedo-Arcique Carlos M, Moran-Muñoz Rafael, Recillas-Morales Sergio

机构信息

Faculty of Veterinary Medicine, Department of Anesthesiology, Universidad Autónoma del Estado de México, El Cerrillo Piedras Blancas, Toluca, Estado de México, Mexico.

Faculty of Veterinary Medicine, Department of Pharmacology, Universidad Autónoma del Estado de México, El Cerrillo Piedras Blancas, Toluca, Estado de México, México.

出版信息

PLoS One. 2015 Nov 25;10(11):e0143710. doi: 10.1371/journal.pone.0143710. eCollection 2015.

DOI:10.1371/journal.pone.0143710

PMID:26605541

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4659611/

Abstract

BACKGROUND

It has been observed that acetaminophen potentiates the analgesic effect of morphine and tramadol in postoperative pain management. Its capacity as an analgesic drug or in combinations thereof to reduce the minimum alveolar concentration (MAC) of inhalational anesthetics represents an objective measure of this effect during general anesthesia. In this study, the effect of acetaminophen with and without morphine or tramadol was evaluated on the isoflurane MAC.

METHODS

Forty-eight male Wistar rats were anesthetized with isoflurane in oxygen. MACISO was determined from alveolar gas samples at the time of tail clamping without the drug, after administering acetaminophen (300 mg/kg), morphine (3 mg/kg), tramadol (10 mg/kg), acetaminophen (300 mg/kg) + morphine (3 mg/kg), and acetaminophen (300 mg/kg) + tramadol (10 mg/kg).

RESULTS

The control and acetaminophen groups did not present statistically significant differences (p = 0.98). The values determined for MACISO after treatment with acetaminophen + morphine, acetaminophen + tramadol, morphine, and tramadol were 0.98% ± 0.04%, 0.99% ± 0.009%, 0.97% ± 0.02%, and 0.99% ± 0.01%, respectively.

CONCLUSIONS

The administration of acetaminophen did not reduce the MAC of isoflurane and did not potentiate the reduction in MACISO by morphine and tramadol in rats, and therefore does not present a sparing effect of morphine or tramadol in rats anesthetized with isoflurane.

摘要

背景

据观察，对乙酰氨基酚在术后疼痛管理中可增强吗啡和曲马多的镇痛效果。其作为镇痛药或与其他药物联合使用时降低吸入麻醉药最低肺泡浓度（MAC）的能力是全身麻醉期间这种效果的客观指标。在本研究中，评估了对乙酰氨基酚单独使用以及与吗啡或曲马多联合使用对异氟烷MAC的影响。

方法

48只雄性Wistar大鼠在氧气中用异氟烷麻醉。在夹尾时采集肺泡气体样本测定无药物时的MACISO，之后分别给予对乙酰氨基酚（300mg/kg）、吗啡（3mg/kg）、曲马多（10mg/kg）、对乙酰氨基酚（300mg/kg）+吗啡（3mg/kg）以及对乙酰氨基酚（300mg/kg）+曲马多（10mg/kg）后再次测定。