丙戊酸盐和卡马西平治疗的青少年癫痫患者的视网膜神经纤维层和黄斑厚度
Retinal nerve fiber layer and macular thickness in adolescents with epilepsy treated with valproate and carbamazepine.
作者信息
Lobefalo Lucio, Rapinese Marcello, Altobelli Emma, Di Mascio Raffaella, Lattanzi Daniela, Gallenga Pier Enrico, Chiarelli Francesco, Verrotti Alberto
机构信息
Department of Experimental Surgery, Section of Ophthalmology, University of Chieti, Italy.
出版信息
Epilepsia. 2006 Apr;47(4):717-9. doi: 10.1111/j.1528-1167.2006.00505.x.
PURPOSE
To evaluate retinal nerve retinal nerve fiber layer (RNFL) and macular thickness by using optical coherence tomography (OCT) in epileptic adolescents before and during monotherapy with valproic acid (VPA) and carbamazepine (CBZ).
METHODS
We examined prospectively 45 epilepsy patients with partial and generalized epilepsy. The patients were evaluated before the beginning of therapy and after 1 year of VPA or CBZ monotherapy. Forty-five untreated healthy controls were evaluated at baseline and after 1 year.
RESULTS
At the beginning of the study, the two groups of patients showed RNFL and macular thickness measurements similar to control values. At the end of the follow-up, the data of the three groups were similar to baseline, showing no significant differences in the evaluated parameters.
CONCLUSIONS
The present study demonstrates that no modification of RNFL and macular thickness parameters is found after 1 year of treatment with VPA and CBZ monotherapy.
目的
采用光学相干断层扫描（OCT）评估癫痫青少年在丙戊酸（VPA）和卡马西平（CBZ）单药治疗前及治疗期间的视网膜神经纤维层（RNFL）和黄斑厚度。
方法
我们前瞻性地检查了45例部分性和全身性癫痫患者。在治疗开始前以及VPA或CBZ单药治疗1年后对患者进行评估。45名未经治疗的健康对照者在基线时和1年后进行评估。
结果
在研究开始时，两组患者的RNFL和黄斑厚度测量值与对照值相似。随访结束时，三组数据与基线相似，在评估参数上无显著差异。
结论
本研究表明，VPA和CBZ单药治疗1年后，RNFL和黄斑厚度参数未发生改变。
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