Salchow Daniel J, Oleynikov Yuri S, Chiang Michael F, Kennedy-Salchow Shana E, Langton Kevin, Tsai James C, Al-Aswad Lama A
Harkness Eye Institute, Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Ophthalmology. 2006 May;113(5):786-91. doi: 10.1016/j.ophtha.2006.01.036.
To measure the peripapillary retinal nerve fiber layer (RNFL) thickness in normal children.
Observational cross-sectional study.
Ninety-two eyes of 92 normal children ages 4 to 17 years presenting to the Ophthalmology Clinic at the Harkness Eye Institute, Department of Ophthalmology, Columbia University.
Retinal nerve fiber layer thickness was measured with optical coherence tomography (OCT). Patient cooperation and signal strength of the OCT scans were assessed. Optic disc photographs were evaluated by a glaucoma specialist in a masked fashion. Eyes with abnormal optic discs were excluded. One eye of each subject was randomly selected for statistical analysis. The effect of several factors on RNFL thickness was investigated statistically.
Retinal nerve fiber layer thickness.
Ninety-one percent of the study subjects were Hispanic; 8%, African American; and 1%, Caucasian. Optical coherence tomography measurements were obtained in 117 of 121 (96.7%) subjects, and disc photographs were available for 92 of them. Mean age (+/-standard deviation [SD]) was 9.7+/-2.7 years. Mean global RNFL thickness (+/-SD) was 107.0+/-11.1 microm (range, 78.1-134.6). The RNFL was thickest inferiorly (136.9+/-16.9 microm) and superiorly (135.4+/-19.3 microm), thinner nasally (83.0+/-18.0 microm), and thinnest temporally (72.5+/-13.4 microm). In univariate regression analysis, age (P = 0.013) and refraction (P<0.001) had a significant effect on RNFL thickness; age had a significant effect on refraction (P<0.001). When controlling for refraction, age no longer had a significant effect.
Optical coherence tomography can be used to measure RNFL thickness in children. Refraction had an effect on RNFL thickness. In normal children, variation in RNFL thickness is large. The normative data provided by this study may assist in identifying changes in RNFL thickness in children.
测量正常儿童视乳头周围视网膜神经纤维层（RNFL）厚度。
观察性横断面研究。
92名4至17岁正常儿童的92只眼睛，这些儿童均就诊于哥伦比亚大学眼科系哈克尼斯眼科研究所的眼科门诊。
采用光学相干断层扫描（OCT）测量视网膜神经纤维层厚度。评估患者的配合程度以及OCT扫描的信号强度。由一名青光眼专家以盲法评估视盘照片。排除视盘异常的眼睛。随机选择每个受试者的一只眼睛进行统计分析。对几个因素对RNFL厚度的影响进行统计学研究。
视网膜神经纤维层厚度。
91%的研究对象为西班牙裔；8%为非裔美国人；1%为白种人。121名受试者中有117名（96.7%）获得了光学相干断层扫描测量结果，其中92名有视盘照片。平均年龄（±标准差[SD]）为9.7±2.7岁。平均整体RNFL厚度（±SD）为107.0±11.1微米（范围为78.1 - 134.6）。RNFL在下方（136.9±16.9微米）和上方（135.4±19.3微米）最厚，鼻侧（83.0±18.0微米）较薄，颞侧（72.5±13.4微米）最薄。在单变量回归分析中，年龄（P = 0.013）和屈光度（P<0.001）对RNFL厚度有显著影响；年龄对屈光度有显著影响（P<0.001）。在控制屈光度后，年龄不再有显著影响。
光学相干断层扫描可用于测量儿童的RNFL厚度。屈光度对RNFL厚度有影响。在正常儿童中，RNFL厚度的变化很大。本研究提供的标准数据可能有助于识别儿童RNFL厚度的变化。
