Cassano Nicoletta, Raho Gabriella, Filieri Maura, D'Argento Vito, Amoruso Antonella, Filotico Raffaele, Vena Gino A
Istituto Dermopatico dell'Immacolata, I.D.I., I.R.C.C.S., Rome, Italy.
Int J Dermatol. 2006 Apr;45(4):394-6. doi: 10.1111/j.1365-4632.2006.02467.x.
Recent findings suggest the involvement of oxidative stress in the pathogenesis of chronic idiopathic urticaria (CIU). It has been demonstrated that desloratadine has an antioxidant activity in vitro. We evaluated the effects of desloratadine on markers of oxidative stress in patients with CIU.
Blood samples were obtained from 10 patients with CIU before and after 4 weeks of treatment with desloratadine. Blood samples from 10 healthy volunteers were used as controls. In platelets from both patients and controls, radical oxygen species (ROS) production was measured using spectrofluorimetric detection of dichloro-fluorescein oxidation, and superoxide dismutase (SOD) activity was determined by means of the xanthine-xanthine oxidase system.
Radical oxygen species concentrations and SOD activity were significantly elevated in patients with CIU at baseline as compared with control subjects. Treatment with desloratadine caused a relevant reduction of ROS levels and SOD activity (P<0.005).
These preliminary results suggest that desloratadine exerts antioxidant effects also in vivo.
最近的研究结果表明氧化应激参与慢性特发性荨麻疹（CIU）的发病机制。已证实地氯雷他定在体外具有抗氧化活性。我们评估了地氯雷他定对CIU患者氧化应激标志物的影响。
采集10例CIU患者在接受地氯雷他定治疗4周前后的血样。10名健康志愿者的血样用作对照。在患者和对照者的血小板中，使用二氯荧光素氧化的荧光分光光度检测法测量活性氧（ROS）的产生，并通过黄嘌呤-黄嘌呤氧化酶系统测定超氧化物歧化酶（SOD）活性。
与对照受试者相比，CIU患者基线时的活性氧浓度和SOD活性显著升高。地氯雷他定治疗使ROS水平和SOD活性显著降低（P<0.005）。
这些初步结果表明地氯雷他定在体内也具有抗氧化作用。
