Lo Su Hao
Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery and Cancer Center, University of California-Davis, Davis, Sacramento, CA 95817, USA.
Dev Biol. 2006 Jun 15;294(2):280-91. doi: 10.1016/j.ydbio.2006.03.029. Epub 2006 Mar 30.
The cytoplasmic side of focal adhesions is comprised of large molecular complexes that link transmembrane receptors, such as integrins, to the actin cytoskeleton and mediate signals modulating cell attachment, migration, proliferation, differentiation, and gene expression. These complexes are heterogeneous and dynamic structures that are apparent targets of regulatory signals that control the function of focal adhesions. Recent studies using genetic approaches in invertebrate and vertebrate systems have begun to reveal the structure and function of these complexes in vivo.
粘着斑的胞质侧由大分子复合物组成，这些复合物将跨膜受体（如整合素）与肌动蛋白细胞骨架相连，并介导调节细胞附着、迁移、增殖、分化和基因表达的信号。这些复合物是异质性的动态结构，显然是控制粘着斑功能的调节信号的作用靶点。最近在无脊椎动物和脊椎动物系统中使用遗传学方法进行的研究已开始揭示这些复合物在体内的结构和功能。
