Petit V, Thiery J P
Subcellular structure and cellular dynamics, UMR 144, CNRS-institut Curie, Paris, France.
Biol Cell. 2000 Oct;92(7):477-94. doi: 10.1016/s0248-4900(00)01101-1.
Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a structural link between the actin cytoskeleton and the extracellular matrix components. Numerous structural and regulatory proteins assemble at the cytoplasmic face of focal adhesions in a Rho-dependent fashion.
细胞与细胞外基质的相互作用对于组织重塑、细胞迁移和胚胎发生的控制至关重要。在细胞与细胞外基质的接触点，会形成特殊结构，称为粘着斑，跨膜粘附受体在其中提供肌动蛋白细胞骨架与细胞外基质成分之间的结构联系。许多结构和调节蛋白以Rho依赖的方式聚集在粘着斑的细胞质面。
