Predel H G, Schulte-Vels O, Glänzer K, Meyer-Lehnert H, Kramer H J
Medizinische Poliklinik, University of Bonn, Germany.
Am J Hypertens. 1991 Nov;4(11):871-9. doi: 10.1093/ajh/4.11.871.
In six patients with essential hypertension (EH) and in six healthy volunteers (C) the effects of a 60-min intravenous (iv) infusion of human atrial natriuretic peptide (alpha-hANP) (24 ng/min/kg) on systemic and renal hemodynamics and renal excretory function were evaluated. Basal plasma ANP concentrations in patients with EH were higher (P less than .05) than in C (30.9 +/- 4.5 v14.0 +/- 1.7 pmol/L). Maximal effects of alpha-hANP infusion occurred after 30 to 60 min. Blood pressure (BP) declined from 154 +/- 5/109 +/- 4 to 139 +/- 7/94 +/- 4 in EH and from 117 +/- 1/72 +/- 2 to 106 +/- 1/65 +/- 3 mm Hg in C (P less than .05). Cardiac output (CO) increased transiently from 6.1 +/- 0.3 to 6.5 +/- 0.4 L/min in EH and from 6.8 +/- 0.3 to 7.2 +/- 0.5 L/min in C, whereas heart rate (HR) remained constant both in patients with EH and in C (69 +/- 3 to 72 +/- 5 and 60 +/- 3 to 63 +/- 3/min). The increases in urine flow and in urinary sodium excretion from 3.6 +/- 0.2 to 16.0 +/- 2.0 mL/min and from 230 +/- 33 to 1004 +/- 137 mumol/min, respectively, in EH were more pronounced than in C (from 3.9 +/- 1.0 to 8.4 +/- 0.8 mL/min and from 211 +/- 37 to 451 +/- 84 mumol/min); (P less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)
对6例原发性高血压（EH）患者和6名健康志愿者（C），评估了静脉输注人心房利钠肽（α-hANP）（24 ng/min/kg）60分钟对全身及肾脏血流动力学和肾脏排泄功能的影响。EH患者的基础血浆ANP浓度高于C组（P<0.05）（30.9±4.5对14.0±1.7 pmol/L）。α-hANP输注的最大效应出现在30至60分钟后。EH组血压（BP）从154±5/109±4降至139±7/94±4，C组从117±1/72±2降至106±1/65±3 mmHg（P<0.05）。EH组心输出量（CO）从6.1±0.3短暂增加至6.5±0.4 L/min，C组从6.8±0.3增加至7.2±0.5 L/min，而EH患者和C组的心率（HR）均保持恒定（69±3至72±5和60±3至63±3次/分钟）。EH组尿流量和尿钠排泄量分别从3.6±0.2增加至16.0±2.0 mL/min和从230±33增加至1004±137 μmol/min，比C组更显著（从3.9±1.0增加至8.4±0.8 mL/min和从211±37增加至451±84 μmol/min）；（P<0.05）。（摘要截断于250字）
