González Huergo D, Rojo Ortega D
Servicio Médico de Mosquitera, Empresa Nacional Hulleras del Norte, S. A.
Rev Esp Enferm Dig. 1991 Aug;80(2):95-8.
We have tested the hypothesis that the intestinal tract has some relation to the absorption of silica particles through the gastrointestinal mucous barrier. Its influence on extrapulmonary silicosis has been seen in experimental and clinical studies. Therefore we used male Wistar rats which were given up to six doses of 50 mg of silica through gastric tube. The animals were sacrificed at the 10th and 41st week. We have not observed silica particles in the submucosa, muscularis or regional lymph nodes. The liver and the spleen did not show silicotic nodules. Our results show that the healthy gastrointestinal barrier plays hardly any part in both silica absorption and extrapulmonary silicosis.
我们已经验证了这样一个假设，即肠道与二氧化硅颗粒通过胃肠道黏液屏障的吸收存在某种关联。在实验和临床研究中已观察到其对肺外矽肺的影响。因此，我们使用了雄性Wistar大鼠，通过胃管给它们喂食多达六剂、每剂50毫克的二氧化硅。在第10周和第41周处死这些动物。我们在黏膜下层、肌层或区域淋巴结中未观察到二氧化硅颗粒。肝脏和脾脏未出现矽结节。我们的结果表明，健康的胃肠道屏障在二氧化硅吸收和肺外矽肺中几乎不起任何作用。
