实验性矽肺大鼠肺部药物吸收增强。

Enhanced pulmonary absorption of drugs in rats with experimental silicosis.

作者信息

Gardiner T H, Schanker L S

出版信息

Res Commun Chem Pathol Pharmacol. 1976 Mar;13(3):559-62.

Abstract

To investigate the effect of pulmonary silicosis on absorption of drugs from the lung, rats were given an intratracheal injection of 50 mg quartz dust, and rates of drug absorption from silicotic and control lungs were compared at 60 and 120 days after treatment. The pulmonary absorption of procaine amide ethobromide and p-aminohippuric acid was increased by 33-41% in animals with silicosis, whereas absorption of procaine amide in silicotic animals was not significantly different from control. The results suggest that silicosis results in an increased porosity of the pulmonary epithelium.

摘要

为研究肺硅沉着病对肺部药物吸收的影响，给大鼠气管内注射50毫克石英粉尘，并在治疗后60天和120天比较硅沉着病大鼠和对照大鼠肺部的药物吸收速率。硅沉着病动物中普鲁卡因胺乙溴化物和对氨基马尿酸的肺部吸收增加了33% - 41%，而硅沉着病动物中普鲁卡因胺的吸收与对照无显著差异。结果表明，硅沉着病导致肺上皮孔隙率增加。