通过人视黄酸受体的短信号序列实现病毒共内化蛋白的核靶向。
Nuclear targeting of a viral-cointernalized protein by a short signal sequence from human retinoic acid receptors.
作者信息
Hamy F, Verwaerde P, Helbecque N, Formstecher P, Hénichart J P
机构信息
INSERM U16, Laboratoire de Biochimie Structurale, Faculté de Médecine, Lille, France.
出版信息
Bioconjug Chem. 1991 Sep-Oct;2(5):375-8. doi: 10.1021/bc00011a013.
PMID:1665078
Abstract
The synthesis of a putative nuclear localization signal from the human retinoic acid receptor is described. Its ability to target a carrier protein to the nucleus is demonstrated following microinjection or a new technique of cell internalization in the presence of adenovirus 3.
摘要
本文描述了源自人类视黄酸受体的一种假定核定位信号的合成。在显微注射后，或在腺病毒3存在的情况下采用一种新的细胞内化技术后，证明了其将载体蛋白靶向细胞核的能力。
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