Raki Mari, Rein Daniel T, Kanerva Anna, Hemminki Akseli
Cancer Gene Therapy Group, Rational Drug Design Program, University of Helsinki, 00014 Helsinki, Finland.
Mol Ther. 2006 Aug;14(2):154-63. doi: 10.1016/j.ymthe.2006.02.019. Epub 2006 May 2.
Gene transfer presents a potentially useful approach for the treatment of diseases refractory to conventional therapies. Various preclinical and clinical strategies have been explored for treatment of gynecological diseases. Given the direst need for novel treatments, much of the work has been performed with gynecological cancers and ovarian cancer in particular. Although the safety of many approaches has been demonstrated in early phase clinical trials, efficacy has been mostly limited so far. Major challenges include improving gene transfer vectors for enhanced and selective delivery and achieving effective penetration and spread within advanced and complex tumor masses. This review will focus on current and developmental gene transfer applications for gynecological diseases.
基因转移为治疗传统疗法难以治愈的疾病提供了一种潜在的有效方法。人们已经探索了各种临床前和临床策略来治疗妇科疾病。鉴于对新型治疗方法的迫切需求，大部分工作都集中在妇科癌症，尤其是卵巢癌上。尽管许多方法的安全性已在早期临床试验中得到证实，但迄今为止疗效大多有限。主要挑战包括改进基因转移载体以实现增强和选择性递送，以及在晚期和复杂肿瘤块中实现有效渗透和扩散。本综述将聚焦于妇科疾病当前及发展中的基因转移应用。
