Kaminetsky Jed C
Department of Urology NewYork University Medical Center, New York, New York 10016, USA.
Clin Cornerstone. 2005;7 Suppl 4:S8-12. doi: 10.1016/s1098-3597(05)80091-2.
Hypogonadism is a common problem in men. It affects 2% to 30% of men aged 40 to 59 years, 20% to 45% aged 60 to 69 years, 34% to 70% aged 70 to 79 years, and most men aged >80 years. Hypogonadism is also highly prevalent in men with chronic illnesses, such as HIV infection. The low testosterone (T) levels associated with hypogonadism impair sexual function and many other aspects of health and well-being. In aging men and in those who are chronically ill, impaired gonadal function is characterized by subtle changes at many stages of T regulation. T therapy reverses the effects of hypogonadism, improving sexual function, body composition, mood, and well-being. Although many forms of T therapy are available, some therapies have limitations that render them ineffective or inconvenient. A new type of T gel has improved pharmacokinetic and clinical profiles compared with other forms of T therapy. This T gel has been shown to be effective in older men and in men with HIV infection, despite unsatisfactory response to earlier T-gel therapy.
性腺功能减退在男性中是一个常见问题。它影响40至59岁男性的2%至30%、60至69岁男性的20%至45%、70至79岁男性的34%至70%，以及大多数80岁以上的男性。性腺功能减退在患有慢性疾病的男性中也非常普遍，如艾滋病毒感染。与性腺功能减退相关的低睾酮（T）水平会损害性功能以及健康和幸福感的许多其他方面。在老年男性和慢性病患者中，性腺功能受损的特征是在睾酮调节的许多阶段都有细微变化。睾酮治疗可逆转性腺功能减退的影响，改善性功能、身体组成、情绪和幸福感。虽然有多种形式的睾酮治疗方法，但有些疗法存在局限性，使其无效或不方便。与其他形式的睾酮治疗相比，一种新型的睾酮凝胶具有更好的药代动力学和临床特征。这种睾酮凝胶已被证明对老年男性和艾滋病毒感染男性有效，尽管他们对早期的睾酮凝胶治疗反应不佳。
