Kilic Sara Sebnem, Kilicbay Fatih
Department of Pediatrics, Uludag University School of Medicine, Bursa, Turkey.
Pediatrics. 2006 Jun;117(6):e1253-1255. doi: 10.1542/peds.2005-2706. Epub 2006 May 1.
We report widely disseminated molluscum contagiosum that occurred in a 9-year-old boy secondary to hyperimmunoglobulin E syndrome, a primary immunodeficiency disorder. Cutaneous examination revealed numerous, widespread, skin-colored to translucent, firm, umbilicated papules of varying sizes. They were distributed throughout the perineal and gluteal areas and bilaterally over his lower limbs. A biopsy specimen from his skin lesion demonstrated lobulated epidermal growth that consisted of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies and a central crater. These findings were consistent with the diagnosis of molluscum contagiosum. Many treatments for his skin lesions were ineffective, including physical destruction or manual extrusion of the lesions; cryotherapy; curettage; and topical therapies with phenol, trichloroacetic acid, and imiquimod. The patient was treated successfully with subcutaneous interferon-alpha for 6 months without any adverse effect.
我们报告了一名9岁男孩继发于高免疫球蛋白E综合征（一种原发性免疫缺陷疾病）而发生的广泛播散性传染性软疣。皮肤检查发现大量广泛分布的、肤色至半透明的、质地坚硬、有脐凹的大小不一的丘疹。它们分布于整个会阴和臀部区域，并双侧分布于下肢。取自其皮肤病变的活检标本显示分叶状表皮增生，由含有大的胞质内嗜酸性包涵体和中央火山口的角质形成细胞组成。这些发现符合传染性软疣的诊断。针对其皮肤病变的多种治疗均无效，包括物理破坏或手动挤压病变、冷冻疗法、刮除术以及使用苯酚、三氯乙酸和咪喹莫特的局部治疗。该患者接受皮下注射α干扰素治疗6个月，治疗成功且无任何不良反应。
