Callinan Pauline A, Feinberg Andrew P
Division of Molecular Medicine, Department of Medicine and Center for the Epigenetics of Common Human Disease, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R95-101. doi: 10.1093/hmg/ddl095.
One of the most exciting frontiers in both epigenetics and genome sciences is the new field of epigenomics. This new discipline promises novel insights into the genome because of its potential to detect quantitative alterations, multiplex modifications and regulatory sequences outside of genes. A number of new epigenomic strategies are emerging to exploit microarray formats with varying substrate choice, pre-processing and data analysis. These approaches are designed to detect large numbers of variations in DNA methylation and chromatin modification. Many groups are joining forces toward developing an organized Human Epigenome Project to exploit these new technologies to better understand the basis of normal development and human disease.
表观遗传学和基因组科学中最令人兴奋的前沿领域之一是表观基因组学这一新领域。由于其有潜力检测基因外的定量改变、多重修饰和调控序列，这一新学科有望为基因组带来全新见解。一些新的表观基因组学策略正在涌现，以利用具有不同底物选择、预处理和数据分析的微阵列形式。这些方法旨在检测DNA甲基化和染色质修饰中的大量变异。许多团队正在携手合作，致力于开展一个有组织的人类表观基因组计划，以利用这些新技术更好地理解正常发育和人类疾病的基础。
