Hatada Izuho
Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8511 Japan.
Crit Rev Oncog. 2006 Dec;12(3-4):205-23. doi: 10.1615/critrevoncog.v12.i3-4.20.
Genome-wide epigenetics, namely, epigenomics, is one of the current frontiers in cancer genomics. Epigenetic silencing of tumor-suppressor genes plays an important role in the pathogenesis of most cancers. Several technologies are emerging for the genome-wide profiling of DNA methylation to find new tumor-suppressor genes and predictions for clinical phenotypes in individual patients.
全基因组表观遗传学，即表观基因组学，是癌症基因组学当前的前沿领域之一。肿瘤抑制基因的表观遗传沉默在大多数癌症的发病机制中起着重要作用。目前正在涌现出几种用于全基因组DNA甲基化分析的技术，以寻找新的肿瘤抑制基因并预测个体患者的临床表型。
