Mont Michael A, Jones Lynne C, Hungerford David S
Center for Joint Preservation and Reconstruction, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA.
J Bone Joint Surg Am. 2006 May;88(5):1117-32. doi: 10.2106/JBJS.E.01041.
The etiology of osteonecrosis of the hip may have a genetic basis. The interaction between certain risk factors and a genetic predisposition may determine whether this disease will develop in a particular individual. The rationale for use of joint-sparing procedures in the treatment of this disease is based on radiographic measurements and findings with other imaging modalities. Early diagnosis and intervention prior to collapse of the femoral head is key to a successful outcome of joint-preserving procedures. The results of joint-preserving procedures are less satisfactory than the results of total hip arthroplasty for femoral heads that have already collapsed. New pharmacological measures as well as the use of growth and differentiation factors for the prevention and treatment of this disease may eventually alter our treatment approach, but it is necessary to await results of clinical research with long-term follow-up of these patients.
髋关节骨坏死的病因可能有遗传基础。某些风险因素与遗传易感性之间的相互作用可能决定该疾病是否会在特定个体中发生。在这种疾病的治疗中采用保留关节手术的依据基于影像学测量以及其他成像方式的检查结果。在股骨头塌陷之前进行早期诊断和干预是保留关节手术取得成功结果的关键。对于已经塌陷的股骨头，保留关节手术的效果不如全髋关节置换术。用于预防和治疗这种疾病的新药物措施以及生长和分化因子的使用最终可能会改变我们的治疗方法，但有必要等待对这些患者进行长期随访的临床研究结果。
