Dubé M C, Joanisse D R, Prud'homme D, Lemieux S, Bouchard C, Pérusse L, Lavoie C, Weisnagel S J
Faculty of Medicine, Department of Physiology and Endocrinology, Laval University, QC, Canada.
Int J Obes (Lond). 2006 Dec;30(12):1721-8. doi: 10.1038/sj.ijo.0803337. Epub 2006 Apr 25.
To compare the relationships between markers of total and regional adiposity with muscle fat infiltration in type 1 diabetic and type 2 diabetic subjects and their respective nondiabetic controls, and to document these relationships in type 1 diabetic subjects.
Cross-sectional study.
In total, 86 healthy, with type 1 diabetes, type 2 diabetes or control subjects. Each diabetic group was matched for age, sex and body mass index with its respective nondiabetic control group.
Measures of body composition (hydrodensitometry), fat distribution (waist circumference, abdominal and mid-thigh computed tomography scans) and blood lipid profiles were assessed.
Low attenuation mid-thigh muscle surface correlated similarly with markers of adiposity and body composition in all groups, regardless of diabetes status, except for visceral adipose tissue and waist circumference. Indeed, relationships between visceral adiposity and muscle adiposity were significantly stronger in type 2 vs type 1 diabetic subjects (P<0.05 for comparison of slopes). In addition, in well-controlled type 1 diabetic subjects (mean HbA(1c) of 6.8%), daily insulin requirements tended to correlate with low attenuation mid-thigh muscle surface, a specific component of fat-rich muscle (r=0.36, P=0.08), but not with glycemic control (HbA(1c)).
This study suggests that the relationship of central adiposity and muscle adiposity is modulated by diabetes status and is stronger in the insulin resistant diabetes type (type 2 diabetes). In well-controlled nonobese type 1 diabetic subjects, the relationship between muscle fat accumulation and insulin sensitivity was also maintained.
比较1型糖尿病和2型糖尿病患者及其各自的非糖尿病对照者中总体和局部肥胖标志物与肌肉脂肪浸润之间的关系，并记录1型糖尿病患者中的这些关系。
横断面研究。
总共86名健康人、1型糖尿病患者、2型糖尿病患者或对照者。每个糖尿病组在年龄、性别和体重指数方面与其各自的非糖尿病对照组相匹配。
评估身体成分（水下密度测定法）、脂肪分布（腰围、腹部和大腿中部计算机断层扫描）和血脂谱。
除内脏脂肪组织和腰围外，所有组中大腿中部低衰减肌肉表面与肥胖和身体成分标志物的相关性相似，无论糖尿病状态如何。事实上，2型糖尿病患者中内脏肥胖与肌肉肥胖之间的关系明显强于1型糖尿病患者（斜率比较P<0.05）。此外，在血糖控制良好的1型糖尿病患者（平均糖化血红蛋白为6.8%）中，每日胰岛素需求量倾向于与大腿中部低衰减肌肉表面相关，这是富含脂肪肌肉的一个特定组成部分（r=0.36，P=0.08），但与血糖控制（糖化血红蛋白）无关。
本研究表明，中心性肥胖与肌肉肥胖之间的关系受糖尿病状态调节，在胰岛素抵抗型糖尿病（2型糖尿病）中更强。在血糖控制良好的非肥胖1型糖尿病患者中，肌肉脂肪堆积与胰岛素敏感性之间的关系也得以维持。
