Murphy Miles, Culligan Patrick J, Arce Cristina M, Graham Carol A, Blackwell Linda, Heit Michael H
University of Louisville HSC, Louisville, Kentucky, USA.
Neurourol Urodyn. 2006;25(5):418-23. doi: 10.1002/nau.20246.
To assess the construct validity of the incontinence severity index (ISI) by testing its correlation with two health-related quality of life measures, the short forms of the Urogenital Distress Inventory (UDI-6) and the Incontinence Impact Questionnaire (IIQ-7), in women with urodynamic stress incontinence.
A cohort of 170 women with the urodynamic stress incontinence who underwent corrective surgery completed the ISI, IIQ-7, and the UDI-6 both pre- and post-treatment. We correlated the pre- and post-treatment responses between the ISI, the IIQ-7, the UDI-6 and their subscales. We also assessed the sensitivity of the ISI to change by correlating the percent change in score between the three instruments. The results were analyzed using a non-parametric test of correlation, the Spearman's rho.
The ISI scores were generally not well correlated with the pre-treatment IIQ-7 and UDI-6 scores (r < 0.40). The post-treatment scores and percent change from pre- to post-treatment of the ISI, however, were highly correlated with that of the IIQ-7 and UDI-6 (r's > 0.70, P < 0.001). The ISI was most highly correlated with the UDI-6 stress symptoms subscale and most poorly correlated with the UDI-6 obstructive/discomfort subscale.
This study provides valuable insight into the construct validity of the ISI. Evidence of its convergent validity is found in the high correlation with the stress symptoms subscales of the UDI-6, while the poorer correlation with the obstructive subscale provides evidence of its divergent validity. These data also suggest that the ISI is highly sensitive to change seen with treatment.
通过测试尿失禁严重程度指数（ISI）与两种健康相关生活质量测量工具，即泌尿生殖系统困扰量表简表（UDI - 6）和尿失禁影响问卷（IIQ - 7）之间的相关性，来评估其在压力性尿失禁女性中的结构效度。
170名接受矫正手术的压力性尿失禁女性队列在治疗前和治疗后均完成了ISI、IIQ - 7和UDI - 6。我们将ISI、IIQ - 7、UDI - 6及其子量表的治疗前和治疗后反应进行相关性分析。我们还通过关联三种工具得分的变化百分比来评估ISI对变化的敏感性。结果采用非参数相关性检验Spearman等级相关系数进行分析。
ISI得分与治疗前IIQ - 7和UDI - 6得分通常相关性不佳（r < 0.40）。然而，ISI治疗后的得分以及治疗前后的变化百分比与IIQ - 7和UDI - 6的得分高度相关（r > 0.70，P < 0.001）。ISI与UDI - 6压力症状子量表相关性最高，与UDI - 6梗阻/不适子量表相关性最差。
本研究为ISI的结构效度提供了有价值的见解。其收敛效度的证据体现在与UDI - 6压力症状子量表的高相关性上，而与梗阻性子量表较差的相关性则提供了其区分效度的证据。这些数据还表明ISI对治疗中出现的变化高度敏感。
