Montalban C, Bellas C, Rodriguez-Garcia J L, Aguado M, Fernandez-Muñoz R
Department of Internal Medicine, Hospital Ramon y Cajal, Madrid, Spain.
Ann Oncol. 1991 Sep;2(8):585-7. doi: 10.1093/oxfordjournals.annonc.a058025.
Hodgkin's disease was diagnosed in a 22-year-old HIV-seropositive man in 1986. Alternate MOPP/ABVD chemotherapy induced a clinical remission. He was asymptomatic until 3 years later when fever and peripheral and mediastinal lymphadenopathy appeared. Lymph node biopsy showed a large-cell anaplastic lymphoma and EBV genome was identified in the malignant cells, suggesting that transformation might had been induced by EBV. The present case affirms that in patients with HIV-related lymphomas who present enlarging lymphadenopathy after stable remission, the development of lymphomas of higher malignancy needs to be ruled out.
1986年，一名22岁的HIV血清阳性男性被诊断为霍奇金病。交替使用MOPP/ABVD化疗诱导了临床缓解。他一直无症状，直到3年后出现发热、外周及纵隔淋巴结肿大。淋巴结活检显示为大细胞间变性淋巴瘤，且在恶性细胞中鉴定出EBV基因组，表示转化可能由EBV诱导。本病例证实，对于HIV相关淋巴瘤患者，在缓解稳定后出现淋巴结肿大，需要排除更高恶性度淋巴瘤的发生。
