Takeuchi J, Miura K, Usizima H, Katoh Y
Acta Pathol Jpn. 1975 Jan;25(1):1-13. doi: 10.1111/j.1440-1827.1975.tb00146.x.
Carcinogens injected into the excretory canal of submandibular gland of Donryu rats revealed the following histologic changes in salivary glands. 20-Methylcholanthrene induced squamous cell metaplasia, fibrosis in the early stages, and "benign lymphoepithelial lesion"-like pattern after 3 months. Dense hyalinization occurred after 4-5 months with so-called "mixed tumor"-like pattern. In the later stages epidermoid carcinoma and fibrosarcoma were observed. 9, 10-Dimethylbenzanthracene caused degenerative change, metaplasia, fibrosis and cell infiltration, and later carcinoma and sarcoma appeared at a high rate. 4-Nitroquinoline-N-oxide led to dense hyalinization and so-called "mixed tumor"-like pattern was observed in many specimens. N-nitroso-N-methyl urethane and N-methyl-N-nitroso-N'-nitroguanidine revealed metaplastic changes, fibrosis and lymphoid infiltration. Scarlet red induced remarkable infiltration and aggregation of lymphoid cells, showing benign "lymphoepithelial lesion"-like pattern.
将致癌物注入到日本大鼠下颌下腺的排泄管中，可观察到唾液腺出现以下组织学变化。20-甲基胆蒽在早期可诱导鳞状上皮化生、纤维化，3个月后出现“良性淋巴上皮病变”样模式。4-5个月后出现致密玻璃样变，伴有所谓的“混合瘤”样模式。后期观察到表皮样癌和纤维肉瘤。9,10-二甲基苯并蒽引起退行性改变、化生、纤维化和细胞浸润，后期出现癌和肉瘤的发生率较高。4-硝基喹啉-N-氧化物导致致密玻璃样变，许多标本中观察到所谓的“混合瘤”样模式。N-亚硝基-N-甲基脲和N-甲基-N-亚硝基-N'-硝基胍表现为化生改变、纤维化和淋巴样浸润。猩红诱导淋巴细胞显著浸润和聚集，呈现良性“淋巴上皮病变”样模式。
