Hindy A M, Shaker M A, Mounir R M
Oral Surgery Department, Faculty of Oral and Dental Medicine, Cairo University.
Egypt Dent J. 1995 Apr;41(2):1195-202.
Carcinogenesis of 35 ddy male mice submandibular salivary glands were attempted; using implants of a 1 mg (2 mm) prepared pellets of the potent chemical carcinogen 9, 10-dimethyl-1, 2-benzanthracene (DMBA) dry powder without a vehicle or carrier. This method appeared to be easy, fast and effective. Within a period ranging from 7-14 weeks; twenty animals developed epidermoid carcinoma (two of them developed squamous cell carcinoma of covering skin as well), and two animals developed mixed tumors (pleomorphic adenoma like tumor) but neither adenocystic carcinoma nor sarcoma were found, the results were adequately discussed.
尝试对35只ddy雄性小鼠的下颌下唾液腺进行致癌作用研究；使用植入1毫克（2毫米）强效化学致癌物9,10-二甲基-1,2-苯并蒽（DMBA）干粉制备的药丸，不使用赋形剂或载体。该方法似乎简便、快速且有效。在7至14周的时间段内，20只动物发生了表皮样癌（其中2只还发生了覆盖皮肤的鳞状细胞癌），2只动物发生了混合瘤（多形性腺瘤样肿瘤），但未发现腺囊性癌或肉瘤，对结果进行了充分讨论。
