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[与脑相关运动障碍发病机制的神经肽因子]

[Neuropeptide factors of pathogenesis of brain-related motor disorders].

作者信息

Makarov A Iu, Vartanian G A, Pomnikov V G, Cherniaev S G, Shatik S V, Tokarev A V

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(10):3-6.

PMID:1665646
Abstract

Overall 136 patients with cerebral tumors, sequels of craniocerebral injury and brain strokes with motor disorders of varying intensity were examined. Factors of the peptide nature, provoking postural asymmetry of the homolateral hind limb in an experimental animal were detected in the blood and CSF of the overwhelming majority of the patients. Provided the compensatory process runs a favorable course (recovery of motor functions), the neuropeptide factors are inactivated with inactivating substances. The data obtained attest to the advisability of further studies into the activity and nature of the factors of postural asymmetry in patients with cerebral motor disorders with a purpose of elaborating new methods of treatment and rehabilitation.

摘要

对136例患有脑肿瘤、颅脑损伤后遗症和中风并伴有不同程度运动障碍的患者进行了检查。在绝大多数患者的血液和脑脊液中检测到了具有肽性质的、在实验动物中引发同侧后肢姿势不对称的因素。如果代偿过程进展顺利(运动功能恢复),神经肽因子会被失活物质灭活。所获得的数据证明,有必要进一步研究脑运动障碍患者姿势不对称因素的活性和性质,以便制定新的治疗和康复方法。

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