Olsen U B, Lund A
Department of Pharmacology, CNS Division, Novo Nordisk A/S, Måløv, Denmark.
Eur J Pharmacol. 1991 Oct 2;203(1):133-5. doi: 10.1016/0014-2999(91)90802-w.
In urethane-anesthetized rats, xylene applied locally to the skin of the hind paws was shown to induce reflex increases of blood pressure (33%) and heart rate (37%). The blood pressure elevation was dose dependently inhibited by the NMDA antagonist, MK-801 (0.3-1.0 mg/kg i.v.), and by the AMPA (D,L-alpha-amino-3-hydroxy-5-methyl-4-isoxalonepropionic acid) antagonist, NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline 0.1-1.0 mg/kg per min). In contrast, only the latter compound was shown to block dose dependently the observed increase in heart rate. The results suggest that the two glutamate antagonists inhibit nociceptive impulse traffic at distinct anatomical sites and/or by different modes of actions.
在氨基甲酸乙酯麻醉的大鼠中，局部应用于后爪皮肤的二甲苯可引起血压反射性升高（33%）和心率反射性升高（37%）。NMDA拮抗剂MK-801（静脉注射0.3 - 1.0mg/kg）和AMPA（D，L-α-氨基-3-羟基-5-甲基-4-异恶唑丙酸）拮抗剂NBQX（2,3-二羟基-6-硝基-7-氨磺酰基-苯并(F)喹喔啉，每分钟0.1 - 1.0mg/kg）可剂量依赖性地抑制血压升高。相反，仅后者被证明可剂量依赖性地阻断观察到的心率升高。结果表明，这两种谷氨酸拮抗剂在不同的解剖部位和/或通过不同的作用方式抑制伤害性冲动传递。
