Calenco-Choukroun G, Daugé V, Gacel G, Roques B P
Pharmacochimie Moléculaire, INSERM U266, CNRS UA498, UFR des Sciences Pharmaceutiques et Biologiques, Paris, France.
Eur J Pharmacol. 1991 Dec 17;209(3):267-71. doi: 10.1016/0014-2999(91)90181-o.
Lesioning of dopamine neurons by injection of 6-hydroxydopamine into the nucleus accumbens blocked the increased rearing activity measured in the open-field and induced by injection into the ventral tegmental area of: [R)-3-(N-hydroxylcarboxamido-2-benzyl-propanoyl)-L-alanine), kelatorphan (complete inhibitor of enkephalin catabolism) or by (Tyr-D-Ser(OtBu)-Gly-Phe-Leu-Thr(OtBu)): BUBU (selective delta agonist) but not the hypolocomotion evoked by the mu agonist (Tyr-D-Ala-Gly-N(Me)-Phe-Glyol): DAMGO. This suggests the involvement of different neuronal pathways in mu and delta effects.
通过向伏隔核注射6-羟基多巴胺来损伤多巴胺神经元，可阻断在旷场中测量到的、由向腹侧被盖区注射[R)-3-(N-羟基羧酰胺基-2-苄基-丙酰基)-L-丙氨酸]、凯拉托品（脑啡肽分解代谢的完全抑制剂）或(Tyr-D-Ser(OtBu)-Gly-Phe-Leu-Thr(OtBu))：BUBU（选择性δ激动剂）所诱导的增强的竖毛活动，但不能阻断μ激动剂(Tyr-D-Ala-Gly-N(Me)-Phe-Glyol)：DAMGO所诱发的运动减少。这表明不同的神经元通路参与了μ和δ效应。
