α1-抗胰蛋白酶缺乏症与肝癌
Alpha1-antitrypsin deficiency and hepatic carcinoma.
作者信息
Schleissner L A, Cohen A H
出版信息
Am Rev Respir Dis. 1975 Jun;111(6):863-8. doi: 10.1164/arrd.1975.111.6.863.
PMID:166582
Abstract
A patient with homozygous ZZ alpha1-antitrypsin deficiency and severe pulmonary emphysema was discovered to have a mixed hepatocellular and cholangiolar hepatic carcinoma arising in a noncirrhotic liver. Because of the increasing frequency of hepatomas in patients with alpha1-antitrypsin deficiency, it is suggested that a causal relationship may exist.
摘要
一名纯合子ZZα1-抗胰蛋白酶缺乏症且患有严重肺气肿的患者被发现患有起源于非肝硬化肝脏的混合性肝细胞和胆管性肝癌。鉴于α1-抗胰蛋白酶缺乏症患者中肝癌的发病率不断上升，提示可能存在因果关系。
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