Parham D M, Paterson J R, Gunn A, Guthrie W
Department of Pathology, Ninewells Hospital and Medical School, Dundee.
Q J Med. 1989 Apr;71(264):359-67.
Two siblings with homozygous ZZ alpha-1-antitrypsin deficiency were discovered to have primary liver tumours (both cholangiocarcinomas). This lends support to the view that alpha-1-antitrypsin deficiency plays a role in the development of some primary liver tumours.
