Okazaki R, Matsumoto T, Harada S, Fukomoto S, Motokura T, Ogata E
Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.
Jpn J Med. 1991 Nov-Dec;30(6):545-7. doi: 10.2169/internalmedicine1962.30.545.
A patient with hypophosphatemic vitamin D-resistant rickets developed secondary erythrocytosis during treatment with large doses of vitamin D2 and phosphate. Erythrocytosis was accompanied by a fall in circulating plasma volume and appeared to have developed as a consequence of nephrocalcinosis because it occurred after the appearance of nephrocalcinosis following several episodes of hypercalcemia and hyperphosphatemia. Nephrocalcinosis and erythrocytosis did not disappear even after recovery of renal function. Thus, the present observations point to the importance of preventing these irreversible complications that could cause renal failure, erythrocytosis, and thrombotic events during the management of hypophosphatemic vitamin D-resistant rickets.
一名低磷性维生素D抵抗性佝偻病患者在大剂量维生素D2和磷酸盐治疗期间出现了继发性红细胞增多症。红细胞增多症伴有循环血浆量减少，似乎是肾钙质沉着症的结果，因为它发生在几次高钙血症和高磷血症后出现肾钙质沉着症之后。即使肾功能恢复，肾钙质沉着症和红细胞增多症也没有消失。因此，目前的观察结果表明，在低磷性维生素D抵抗性佝偻病的治疗中，预防这些可能导致肾衰竭、红细胞增多症和血栓形成事件的不可逆并发症非常重要。
