Inamo Y, Takeuchi S, Okuni M
Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan.
Acta Paediatr Jpn. 1991 Oct;33(5):628-32. doi: 10.1111/j.1442-200x.1991.tb01876.x.
Host responses and neuroendocrinological changes during pyrexia in childhood were studied. Serum IL-1 beta could not be detected in most subjects either during pyrexia or in afebrile periods. IL-1 beta was detected in two cases, increasing during pyrexia and decreasing during the afebrile period. Plasma ACTH increased during pyrexia, but this was not statistically significant. Serum cortisol during pyrexia increased to around twice the normal value, and many subjects showed a high level of arginine vasopressin. The subjects, who did not develop dehydration, showed a decrease in serum osmolality and serum sodium during the pyrexia period. Serum Fe and Zn decreased, but serum Cu increased during both periods. It could not be confirmed that IL-1 activates the hypothalamic-pituitary-adrenal axis during pyrexia. It is concluded that AVP is important in the control of fever and the maintenance of homeostasis of body fluid during pyrexia.
对儿童发热期间的宿主反应和神经内分泌变化进行了研究。在大多数受试者的发热期或体温正常期均未检测到血清白细胞介素-1β（IL-1β）。在两例中检测到IL-1β，其在发热期升高，在体温正常期降低。发热期间血浆促肾上腺皮质激素（ACTH）升高，但无统计学意义。发热期间血清皮质醇升高至正常值的两倍左右，许多受试者显示精氨酸加压素（AVP）水平较高。未发生脱水的受试者在发热期血清渗透压和血清钠降低。血清铁和锌降低，但两个时期血清铜均升高。无法证实IL-1在发热期间激活下丘脑-垂体-肾上腺轴。得出的结论是，AVP在发热控制和发热期间维持体液稳态中起重要作用。
