Department of Biological Sciences, Stanford University, Stanford, California 94305.
Plant Physiol. 1976 Oct;58(4):592-4. doi: 10.1104/pp.58.4.592.
Chloramphenicol, an inhibitor of mitochondrial protein synthesis, shortened the period length of the circadian rhythm in the Timex strain of Neurospora crassa by 2 hours. Both the l(+) threo and d(-) threo optical isomers had the same effect on the period of the rhythm, whereas only the d(-) threo isomer significantly inhibited mitochondrial protein synthesis. Tetracycline, another inhibitor of mitochondrial protein synthesis, did not change the period of the circadian rhythm. The effect of chloramphenicol on the circadian rhythm is, therefore, presumably not directly related to inhibition of mitochondrial protein synthesis, suggesting that chloramphenicol has other effects.
氯霉素是一种线粒体蛋白质合成抑制剂，可将 Neurospora crassa 的 Timex 菌株的生物钟节律周期缩短 2 小时。l(+)苏式和 d(-)苏式两种光学异构体对节律周期都有相同的作用，而只有 d(-)苏式异构体显著抑制了线粒体蛋白质的合成。另一种线粒体蛋白质合成抑制剂四环素则没有改变生物钟节律的周期。因此，氯霉素对生物钟节律的影响可能与抑制线粒体蛋白质合成无关，这表明氯霉素可能有其他作用。
