Papanastasiou D A, Papanicolaou D, Magiakou A M, Beratis N G, Tzebelikos E, Papapetropoulos T
University of Patras Medical School, Regional University Hospital of Patras, Greece.
J Neurol Neurosurg Psychiatry. 1991 Nov;54(11):997-1000. doi: 10.1136/jnnp.54.11.997.
As some patients with beta-thalassaemia manifested neurological signs, clinical and electrophysiological investigations were carried out on 53 thalassaemic patients and 29 healthy control subjects. Twenty per cent of the patients showed clinical and electrophysiological findings of a mild peripheral sensorimotor neuropathy, mainly of the lower limbs. The clinical symptoms were numbness, pins and needles sensations, muscular cramps, myalgia and muscle weakness. The electrophysiological abnormalities were manifested by decreased motor conduction velocity (MCV) and prolonged F-wave latencies of the tibial and the peroneal nerves. Borderline increase in the latencies of the sensory potentials of the median nerve was also observed. The electromyographic findings of the patients with diminished MCVs were compatible with a predominantly motor peripheral neuropathy. This neuropathy appears during the second and third decade of life.
由于一些β地中海贫血患者出现了神经学体征，因此对53例地中海贫血患者和29名健康对照者进行了临床和电生理检查。20%的患者表现出轻度周围感觉运动神经病的临床和电生理结果，主要累及下肢。临床症状包括麻木、刺痛感、肌肉痉挛、肌痛和肌肉无力。电生理异常表现为运动传导速度（MCV）降低以及胫神经和腓总神经F波潜伏期延长。还观察到正中神经感觉电位潜伏期有临界性延长。MCV降低的患者的肌电图结果与以运动为主的周围神经病相符。这种神经病出现在生命的第二个和第三个十年。
