Navarro M, Mur E, Jolis L, Bellmunt J, Bodi R, Solé L A, Rubio D
Hospital Valle Hebrón, Barcelona.
Rev Clin Esp. 1991 Oct;189(5):209-12.
The results obtained from 23 patients suffering small cell lung carcinoma limited to the thorax, treated with 4 cycles of cyclophosphamide, adriamycin, vincristine alternating with cisplatin and VP/16, followed by mediastinal and holocranial prophylactic radiotherapy in patients with a complete response (CR) are here presented. An 87% of global responses were obtained with a 64% rate of RC. The average survival rate was 12 months with an 18% of patients alive two years after treatment. The main toxicity was hematologic and neurologic. Even if this alternating regime produces a high response rate, the results are not superior to those obtained with conventional chemotherapy.
本文呈现了23例局限于胸部的小细胞肺癌患者的治疗结果。这些患者接受了4个周期的环磷酰胺、阿霉素、长春新碱与顺铂及依托泊苷交替治疗，对完全缓解（CR）的患者随后进行纵隔和全颅预防性放疗。总体缓解率为87%，完全缓解率为64%。平均生存率为12个月，18%的患者在治疗后两年仍存活。主要毒性为血液学和神经学毒性。即使这种交替方案产生了较高的缓解率，但其结果并不优于传统化疗。
