Hamasaki Y, Miyazaki S
Department of Pediatrics, Saga Medical School, Japan.
Acta Paediatr Jpn. 1991 Dec;33(6):771-7. doi: 10.1111/j.1442-200x.1991.tb02607.x.
The role of LTB4 in Kawasaki disease as a chemo-attractant and immunomodulator is reviewed through our own experience and reports by other investigators. In our experiment using 19 patients, we measured calcium ionophore-stimulated LTB4 synthesis in PMNs obtained in three different stages of the illness (acute, convalescent and recovered phases). LTB4 synthesis was significantly increased in the convalescent phase of the illness. Other investigators showed increased serum-LTB4 concentration in acute as well as convalescent phases, suggesting that LTB4 participated in the inflammatory process of Kawasaki disease as an inflammatory mediator and immunomodulator. However, no difference was found in LTB4 synthetic activity in PMNs in any phases of the illness between the patients with and without coronary lesions, which indicated that LTB4 was not a parameter of coronary aneurysm formation. Therapeutic use of high-dose gamma-globulin showed a tendency to decreased LTB4 synthesis in PMNs, although it is not conclusive.
通过我们自己的经验以及其他研究者的报告，对白三烯B4（LTB4）在川崎病中作为趋化因子和免疫调节剂的作用进行了综述。在我们对19例患者进行的实验中，我们测量了在疾病的三个不同阶段（急性期、恢复期和康复期）获得的多形核白细胞（PMN）中钙离子载体刺激的LTB4合成。在疾病的恢复期，LTB4合成显著增加。其他研究者表明，在急性期和恢复期血清LTB4浓度均升高，这表明LTB4作为炎症介质和免疫调节剂参与了川崎病的炎症过程。然而，在有冠状动脉病变和无冠状动脉病变的患者之间，疾病任何阶段的PMN中LTB4合成活性均未发现差异，这表明LTB4不是冠状动脉瘤形成的一个参数。高剂量丙种球蛋白的治疗应用显示出PMN中LTB4合成有降低的趋势，尽管尚无定论。
