Hamasaki Y, Miyazaki S
Department of Pediatrics, Saga Medical School.
Arerugi. 1990 Mar;39(3):354-60.
It is postulated that inflammatory cells play an important role in the process of developing vasculitis in Kawasaki Disease. LTB4, a 5-lipoxygenase product of arachidonic acid is one of the most potent chemoattractants to inflammatory cells and is produced in large amounts by PMNs. We investigated the role of PMN-derived LTB4 in Kawasaki Disease. Isolated PMNs were obtained from 19 Kawasaki disease patients in three different phases of the illness, (acute phase: 0-12th day, convalescent phase: 13-29th day, restored phase: greater than 30th day). LTB4 synthesis in the convalescent phase was 26.43 +/- 4.2 ng/5 x 10(6) cells, which was significantly higher than those in the acute and restored phases (11.90 +/- 1.91, 13.87 +/- 1.86 ng) and also higher than that in the control subjects (10.65 +/- 1.26 ng: p less than 0.05). No differences were found between two groups with or without coronary lesions. The results imply that activated PMNs during the convalescent phase of illness produce larger amount of LTB4 which may participate in the development of inflammatory process of the disease and that PMN-derived LTB4 plays no significant roles in the development of coronary lesions.
据推测，炎症细胞在川崎病血管炎的发展过程中起重要作用。白三烯B4（LTB4）是花生四烯酸的5-脂氧合酶产物，是对炎症细胞最有效的趋化因子之一，由中性粒细胞大量产生。我们研究了中性粒细胞衍生的LTB4在川崎病中的作用。从19例处于疾病三个不同阶段的川崎病患者中获取分离的中性粒细胞，（急性期：第0 - 12天，恢复期：第13 - 29天，恢复后期：大于第30天）。恢复期LTB4的合成量为26.43±4.2 ng/5×10(6)个细胞，显著高于急性期和恢复后期（分别为11.90±1.91、13.87±1.86 ng），也高于对照组（10.65±1.26 ng：p＜0.05）。在有或无冠状动脉病变的两组之间未发现差异。结果表明，疾病恢复期活化的中性粒细胞产生大量的LTB4，这可能参与了疾病炎症过程的发展，并且中性粒细胞衍生的LTB4在冠状动脉病变的发展中不起重要作用。
