Tian Y L
General Hospital, PLA, Beijing.
Zhonghua Jie He He Hu Xi Za Zhi. 1991 Aug;14(4):202-4, 254.
Sixty male Wistar rats were randomized into six groups. In the control and injury group normal saline and oleic acid were injected in tail veins respectively. Dexamethasone, Salviae mitiorrhizae, Ligustrazini and phenobarbitalum natrium were intraperitoneally for the other four groups 15 minutes before the intravenous injection of oleic acid separately. The results showed that the Bmax of beta-adrenoceptor in injury group were decreased markedly and there was correlation between the decreasing of beta-adrenoceptor numbers and pathologic damage in acute lung injury rat. The Bmax of beta-adrenoceptor in cortisone group were similar to control group, which indicated that cortisone is effective to prevent pathologic damage from lung injury by maintenance of the activity of beta-adrenoceptor.
将60只雄性Wistar大鼠随机分为6组。对照组和损伤组分别经尾静脉注射生理盐水和油酸。在静脉注射油酸前15分钟，对其他4组分别腹腔注射地塞米松、丹参、川芎嗪和苯巴比妥钠。结果显示，损伤组β-肾上腺素受体的最大结合容量（Bmax）显著降低，急性肺损伤大鼠β-肾上腺素受体数量的减少与病理损伤之间存在相关性。可的松组β-肾上腺素受体的Bmax与对照组相似，这表明可的松通过维持β-肾上腺素受体的活性对预防肺损伤的病理损害有效。
