Zlenko E T, Demchenko E M
Farmakol Toksikol. 1991 Nov-Dec;54(6):18-20.
In the experiments on rats of different ages it was found that the analgesic effect of clopheline was stronger in the adult animals as compared with 1-month-old ones. Against the background of the operative trauma (laparotomy) the inversion of the effect occurs, namely clopheline exerts a more potent analgesic effect of clopheline in young animals. Simultaneously in the young animals there is observed suppression of the memory processes based on the nociceptive reinforcement. The potentiation of the analgesic effect of clopheline in 1-month-old animals is followed by an increase of the activity of Na+, K(+)-ATPase in the brain cortex the degree of which (two times) corresponds to the rise of the analgesic effect.
在对不同年龄大鼠进行的实验中发现，与1月龄大鼠相比，氯苯乙脒在成年动物中的镇痛作用更强。在手术创伤（剖腹术）背景下，这种作用会发生反转，即氯苯乙脒在幼龄动物中发挥更强的镇痛作用。同时，在幼龄动物中观察到基于伤害性强化的记忆过程受到抑制。1月龄动物中氯苯乙脒镇痛作用的增强伴随着大脑皮层中Na +、K(+)-ATP酶活性的增加，其增加程度（两倍）与镇痛作用的增强相对应。
