Kasckow J, Nemeroff C B
Neurobiochemistry Group, UCLA School of Medicine.
Regul Pept. 1991 Oct 29;36(2):153-64. doi: 10.1016/0167-0115(91)90053-j.
Neurotensin (NT) is a tridecapeptide which fulfills many of the requisite criteria for a role as a central nervous system (CNS) neurotransmitter. It is closely associated with CNS dopamine neurons and has been shown to interact with dopamine at physiological, anatomical and behavioral levels. Neurotensin is colocalized with dopaminergic neurons in the hypothalamus and midbrain. In addition, it blocks behaviors associated with activation of the dopaminergic pathways. Centrally administered NT has been shown to mimic many of the actions of antipsychotic drugs. In addition, the concentration of NT in cerebrospinal fluid is decreased in patients with schizophrenia. Administration of clinically effective antipsychotic drugs increases concentrations of NT in the caudate nucleus and nucleus accumbens. NT has been shown to play a role in signal transduction by mostly mobilizing calcium stores following inositol phosphate formation. This has been linked to subsequent events in protein phosphorylation. Lipophilic NT receptor agonists may represent a novel approach to the development of a new class of antipsychotic drugs.
神经降压素（NT）是一种十三肽，满足作为中枢神经系统（CNS）神经递质的许多必要标准。它与中枢神经系统多巴胺神经元密切相关，并且已被证明在生理、解剖和行为水平上与多巴胺相互作用。神经降压素与下丘脑和中脑的多巴胺能神经元共定位。此外，它会阻断与多巴胺能通路激活相关的行为。已证明中枢给予神经降压素可模拟许多抗精神病药物的作用。此外，精神分裂症患者脑脊液中神经降压素的浓度会降低。给予临床有效的抗精神病药物会增加尾状核和伏隔核中神经降压素的浓度。已证明神经降压素主要通过在肌醇磷酸形成后动员钙库来参与信号转导。这与蛋白质磷酸化的后续事件有关。亲脂性神经降压素受体激动剂可能代表了开发新型抗精神病药物的一种新方法。
